Torulopsis glabrata. Morphologic characteristics, biotyping and sensitivity to isolates of antifungal agents in vitro]

The authors described morphological and biochemical properties of twenty strains of Torulopsis glabrata and two strains of T. candida and T. sphaerica, mostly of human origin. By means of eight biotyping tests based on the evaluation of so-called resistograms the isolates of T. glabrata were divided into eight biotypes. The authors discussed the problem of possible use of biotyping of T. glabrata in investigations of the epidemiology and pathogenesis of mycoses caused by this microorganism. In investigations of the sensitivity of strains of Torulopsis spp. to nine antimycotic agents in vitro it was revealed that the isolates were sensitive to all polyene antibiotics (amphotericin B, nystatin and pimaricin) and to 5-fluorocytosine. The sensitivity to azole chemotherapeutic agents (clotrimazole, econazole, miconazole, ketoconazole and itraconazole) was more varied: some strains were resistant to clotrimazole and econazole.