61例药疹伴药物性肝损害住院病例临床分析

目的了解致敏药物引起药物性肝损害在排序上与所致药疹的发生率是否相同.方法对1998年9月至2003年3月在我科住院并已经确诊为药疹的261例患者中伴有药物肝脏损害的61例进行了回顾性的分析.结果引起药疹并容易导致肝损害的致敏药物是抗病毒类为60%(9/15),抗痨类药物为66.67%(8/12),别嘌呤醇55.56%(5/9).结论对本组回顾性分析发现各种致敏药物引起药物性肝脏损害在排序上与所致药疹发生率有所不同,故在临床治疗用药以及药疹诊治方面应值得注意.

Clinical analysis of 61 cases of drug eruptions complicated with drug-induced liver dysfunction

Objective To investigate whether the sort of drugs causing drug eruptions complicated with drug-induced liver dysfunction are the same as those causing drug eruptions. Methods Sixty-one cases of drug eruption complicated with drug-induced liver dysfunction in 261 cases confirmed as drug eruptions from January 1998 to March 2003 were analyzed retrospectively. Results The major hepatotoxic drugs in these cases were antivirus drugs (60%, 9/15), antituberculosis drugs (66.67%, 8/12), zyloric (55.56%, 5/9), and some traditional Chinese medicines (31.58%, 6/19). Conclusion The sort of drugs causing drug eruptions complicated with drug-induced liver dysfunction are the same as those causing drug eruptions, which should be taken into consideration in clinical medication.