贝伐珠单抗治疗非小细胞肺癌脑转移的研究进展

脑部是肺癌最常见的远处器官转移部位之一，肺癌脑转移的发生率高，是脑转移性肿瘤中最常见的类型，同时也是肺癌死亡率居高不下的原因之一。抗肿瘤血管生成治疗已成为肺癌治疗的重要手段之一，抗血管生成药物贝伐珠单抗也成为继全脑放疗、立体定位放疗和化疗之后肺癌脑转移患者新的治疗选择。目前，对脑转移的非小细胞肺癌患者应用贝伐珠单抗治疗的临床研究也越来越多，其安全性和有效性是研究重点。本文就贝伐珠单抗治疗非小细胞肺癌脑转移的研究进展做一综述。

Advances in Bevacizumab Therapy for Non-small Cell Lung Cancer with Brain Metastases

Brain metastases are frequently encountered in patients with non-small cell lung cancer (NSCLC) and are a signiifcant cause of morbidity and mortality. Antiangiogenesis therapy plays a major role in the management of brain metastases in lung cancer. Bevacizumab have become the novel method for the treatment of lung cancer with brain metastases beyond the whole brain radiation therapy, stereotactic radiosurgery and chemotherapy. Recently, more and more studies and trials laid emphasis on the bevacizumab for NSCLC with brain metastases treatment. hTe key point is the effcacy and safety. In this review, bevacizumab therapy of NSCLC with brain metastases were summarized.