肺癌筛查方法现状

肺癌是目前恶性肿瘤死亡的首要原因，早期诊断对肺癌的预后至关重要。研究显示低剂量计算机断层扫描（computed tomography, CT）筛查可以使肺癌的死亡率下降。但其存在的问题不可忽视，如过高的假阳性率、过度诊断、辐射效应等。作为一种肿瘤无创筛查方法，血液相关肿瘤标志物的检测，在肺癌早期诊断中显示出良好的敏感性和特异性。如何利用现有的筛查手段，建立肺癌筛查综合模式，需要更多大规模的临床研究。

Present Situation of Lung Cancer Screening Methods

Lung cancer is the leading cause of cancer mortality currently. Early diagnosis is crucial to the good prognosis of lung cancer. Evidence has shown that low-dose computed tomography (CT) screening can make the decline in the mortality of lung cancer. However, there are still many problems in the screening, such as, high false-positive rates, overdiagno-sis and radiation exposure. As another non-invasive tumor screening method, blood-based tumor markers showed a high sen-sitivity and speciifcity in early diagnosis of lung cancer in recent years. How to establish a comprehensive mode for lung cancer screening by use existing screening methods, we need more clinical research.