早期非小细胞肺癌个体化手术策略与术中冰冻病理的指导

早期非小细胞肺癌尤其是电子计算机断层扫描（computed tomography, CT）筛查出的微小的在影像学表现为磨玻璃密度样（ground-glass opacity, GGO）的肺癌在亚洲人群中逐渐增多。临床回顾性数据表明对此类患者施行亚肺叶切除术疗效可能并不次于肺叶切除，而且保留了更多的肺功能。研究证明除仔细地评估术前影像表现外，术中冰冻病理诊断为原位腺癌或微浸润肺腺癌可能更适合做亚肺叶切除。更精准的个体化手术策略应基于术中快速冰冻病理诊断。

Strategies of Individual Surgical Treatment for Early Stage Non-small Cell Lung Cancer and the Guidance of Intraoperative Frozen Pathology

Early stage non-small cell lung cancer patients, especially those who presented small GGO on image, are increasing in Asia population. Retrospective clinical data indicated that the effcacy of sub-lobectomy for these patients may be non-inferior to that of lobectomy. Meanwhile, sub-lobectomy could preserve more pulmonary function for the patients. Researches have demonstrated that careful evaluation for the image manifestation is essential before sub-lobectomy and those who diagnosed as adenocarcinoma in situ or minimally invasive adenocarcinoma may be more appropriate for this procedure. Precise diagnosis of Intraoperative frozen section is an effective method toward personalization of surgical care for early-stage non-smallcell lung cancer.