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| 职业接触抗肿瘤药物对护士外周血淋巴细胞凋亡及Fas bcl-2基因表达的影响 | |
| 引用本文： | 李茂莲,张月英,肖传实,王清馨,裴毅. 职业接触抗肿瘤药物对护士外周血淋巴细胞凋亡及Fas bcl-2基因表达的影响[J]. 中国药物与临床, 2005, 5(12): 899-901 |
| 作者姓名： | 李茂莲 张月英 肖传实 王清馨 裴毅 |
| 作者单位： | 1. 山西医科大学第二医院消化内窥镜科,030001 2. 山西医科大学第二医院影像科,030001 3. 山西医科大学第二医院心内科,030001 4. 山西省肿瘤医院消化科 |
| 摘 要： | 目的探讨职业接触抗肿瘤药物对护士外周血淋巴细胞凋亡及Fas、bcl-2基因表达的影响。方法选择接触抗肿瘤药物5年以上,每日接触5人次以上的护士为接触组;无抗肿瘤药物接触史的健康志愿者为对照组。抽取接触组及正常对照组外周静脉血各2ml,乙二胺四乙酸(EDTA)抗凝,利用流式细胞仪技术观察外周血淋巴细胞凋亡率及Fas、bcl-2基因的表达。结果接触组外周血淋巴细胞凋亡率明显增高(P<0.05);接触组Fas基因的表达明显增高(P<0.01);而bcl-2基因表达差异无统计学意义。结论抗肿瘤药物能促进职业接触护士外周血淋巴细胞的凋亡和Fas基因的表达。 |
| 关 键 词： | 抗肿瘤药 职业暴露 细胞凋亡 基因,bcl-2 基因,Fas |
| 收稿时间： | 2005-09-13 |
| 修稿时间： | 2005-09-13 |
Effects of antineoplastic agents on lymphocyte apoptosis and Fas bcl-2 gene expression in nurses with occupational exposure to them |
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| LI Mao-lian,ZHANG Yue-ying,XIAO Chuan-shi,WANG Qing-xin,PEI Yi. Effects of antineoplastic agents on lymphocyte apoptosis and Fas bcl-2 gene expression in nurses with occupational exposure to them[J]. Chinese Remedies & Clinics, 2005, 5(12): 899-901 | |
| Authors: | LI Mao-lian ZHANG Yue-ying XIAO Chuan-shi WANG Qing-xin PEI Yi |
| Abstract: | Objective To study the effects of antineoplastic agents on lymphocyte apoptosis and expression of Fas,bcl-2 gene in nurses with occupational exposure to these drugs. Methods By using flow cytometric technique,lymphocyte apoptosis and expression of Fas,bcl-2 gene were assessed. Results Lymphocyte apoptosis in nurses with occupational exposure to antineoplastic drugs significantly increased (P<0.05). Fas gene expression of nurses in occupationally exposed group also significantly increased (P<0.01).Difference in bcl-2 gene expressions showed no statistical significance. Conclusion Antineoplastic agents can increase lymphocyte apoptosis and Fas gene expression in nurses with occupational exposure to these drugs. |
| Keywords: | Antineoplastic agents Occupational exposure Apoptosis Gene bcl-2 Gene Fas |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |