Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients |
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| Authors: | WATTANA CHEUNOY,MELLES HAILE,ANGKANA CHAIPRASERT,THERDSAK PRAMMANANAN,MARIANA CRISTEA‐FERNSTR
M,MARTIN VONDRACEK,ERJA CHRYSSANTHOU,SVEN HOFFNER,BJ
RN PETRINI |
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| Affiliation: | 1. Department of Clinical Microbiology, Karolinska University Hospital and Karolinska Institute, Stockholm;2. Tuberculosis Unit, Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden;3. Molecular Mycology and Mycobacteriology Laboratory, Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok;4. Anti‐Tuberculous Drug Research Laboratory, National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Nonthaburi, Thailand |
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| Abstract: | The aim of this study was the molecular characterization of primary drug‐resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug‐resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single‐drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug‐resistant TB. |
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| Keywords: | Tuberculosis drug resistance MDR‐TB XDR‐TB DR‐TB Beijing genotype |
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