Comprehensive Biomarker Testing of Glycemia,Insulin Resistance,and Beta Cell Function Has Greater Sensitivity to Detect Diabetes Risk Than Fasting Glucose and HbA1c and Is Associated with Improved Glycemic Control in Clinical Practice |
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| Authors: | Stephen A. Varvel Szilard Voros Dawn L. Thiselton James V. Pottala Tara Dall G. Russell Warnick Joseph P. McConnell Leila Ghaedi Maciek Sasinowski Timothy Graham |
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| Affiliation: | 1. Health Diagnostic Laboratory, Inc., 737, Richmond, VA, 23219, USA
2. University of Utah, Salt Lake City, UT, USA
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| Abstract: | Blood-based biomarker testing of insulin resistance (IR) and beta cell dysfunction may identify diabetes risk earlier than current glycemia-based approaches. This retrospective cohort study assessed 1,687 US patients at risk for cardiovascular disease (CVD) under routine clinical care with a comprehensive panel of 19 biomarkers and derived factors related to IR, beta cell function, and glycemic control. The mean age was 53?±?15, 42 % were male, and 25 % had glycemic indicators consistent with prediabetes. An additional 45 % of the patients who had normal glycemic indicators were identified with IR or beta cell abnormalities. After 5.3 months of median follow-up, significantly more patients had improved than worsened their glycemic status in the prediabetic category (35 vs. 9 %; P?HbA1c values of 5.5–5.6; 56 vs. 18 %, p?
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