| 化疗药物所致的内分泌紊乱 |
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| 引用本文： | 刘欣,洪小南. 化疗药物所致的内分泌紊乱[J]. 中国癌症杂志, 2007, 17(8): 663-666 |
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| 作者姓名： | 刘欣 洪小南 |
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| 作者单位： | 复旦大学附属肿瘤医院肿瘤内科,复旦大学上海医学院肿瘤学系,上海200032 |
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| 摘 要： | 抗肿瘤药物所致的内分泌紊乱在临床上并不少见,但由于其临床表现隐匿,症状错综复杂,临床上不易辨认,特别是与特定化疗药物的关系,难以鉴别.本综述按化疗药物所致内分泌系统功能紊乱的类型分别进行阐述,如糖代谢、脂代谢、无机物代谢紊乱,性腺、甲状腺功能障碍,水清除异常,肾上腺功能异常,生长激素的分泌或生长异常,代谢性骨病等.早期发现和早期治疗内分泌功能障碍,可以显著提高癌症患者的生命质量和生存时间.
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| 关 键 词： | 抗肿瘤药物 化疗 不良反应 内分泌系统疾病 |
| 文章编号： | 1007-3639（2007）08-0663-04 |
| 修稿时间： | 2007-04-06 |
Endocrine system disturb induced by antineoplastic agents |
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| LIU Xin,HONG Xiao-nan. Endocrine system disturb induced by antineoplastic agents[J]. China Oncology, 2007, 17(8): 663-666 |
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| Authors: | LIU Xin HONG Xiao-nan |
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| Affiliation: | Department of Medical Oncology, Cancer Hospital, Fudan University, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | Effects of antineoplastic agents on endocrine system are common, but it is difficult to identify since clinical complaints are subtle, and even more difficult to relate a particular chemotherapeutic regimen to the induced endocrine disturb. This review was organized according to the pattern of endocrine system diseases induced by antineoplastic agents, such as disorders of glucose metabolism, free water clearance, mineral metabolism, lipid metabolism and GH secretion and growth, metabolic bone diseases, adrenal dysfunction, thyroid disorders and reproductive dysfunction. Early detection and treatment of endocrine deficiency may have a significant impact on the quality and duration of life in a cancer survivor. |
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| Keywords: | antineoplastic agents chemotherapy adverse effects endocrine system disease |
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