| COX-2与乳腺癌的发生发展 |
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| 引用本文： | 刘锦,李贵新. COX-2与乳腺癌的发生发展[J]. 国际病理科学与临床杂志, 2008, 28(5): 13-428 |
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| 作者姓名： | 刘锦 李贵新 |
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| 作者单位： | 潍坊医学院,山东,潍坊,261031 |
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| 摘 要： | 环氧合酶（cyclooxygenase，COX）是花生四烯酸合成前列腺素的限速酶。乳腺癌组织内环氧合酶-2的表达可能增加乳腺癌细胞的活性和侵袭力，增加前列腺素产物的生成，抑制乳腺癌细胞的凋亡等,与乳腺癌的发生、发展及预后有关。因此，应用COX-2抑制剂治疗乳腺癌成为目前的研究热点。
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| 关 键 词： | 环氧合酶-2 乳腺肿瘤 抑制剂 |
| 收稿时间： | 2008-03-12 |
| 修稿时间： | 2008-04-26 |
Cyclooxygenase-2 and the development of breast cancer |
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| LIU Jin,LI Gui-xin. Cyclooxygenase-2 and the development of breast cancer[J]. Journal of International Pathology and Clinical Medicine, 2008, 28(5): 13-428 |
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| Authors: | LIU Jin LI Gui-xin |
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| Affiliation: | Weifang Medical University, Weifang Shangdong 261031, China |
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| Abstract: | Cyclooxygenase(COX) is the rate-limiting enzmyme for the conversion of arachidonic acid into prostaglandin(PG).COX-2 expression is associated with generation,development and prognosis of breast cancer.It may increase motility and invasion of breast cancer cells,the production of prostaglandin product,inhibit breast cancer cells apoptosis.Thus the research of COX-2 inhibitors for treating breast cancer becomes a hot issue at present. |
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| Keywords: | cyclooxygenase-2 breast tumor inhibitor |
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