Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas |
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| Authors: | Papp T Schipper H Pemsel H Unverricht M Muller K M Wiethege T Schiffmann D Rahman Q |
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| Affiliation: | Department of Biological Sciences, Institute for Cell Biology and Biosystems Technology, University of Rostock, D-18051 Rostock, Germany. thilo.papp@biologie.uni-rostock.de |
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| Abstract: | Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not frequently involved in mesothelioma formation. |
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