高通量药物筛选在新药研究中的应用

高通量药物筛选技术是 2 0世纪 80年代后期形成的寻找新药的高新技术。经过十余年的实践 ,该技术体系不断发展和完善 ,成为目前寻找新药的重要手段。应用高通量药物筛选技术寻找新药 ,不仅改变了人们对药物筛选的认识 ,同时对药物开发研究的思路也产生了明显的冲击。如何应用高通量药物筛选开发新药 ,已成为目前药物研究中的重要课题之一。本文根据药物发现的基本规律 ,介绍高通量药物筛选的发展过程和基本原理方法 ,探讨高通量药物筛选在新药发现中的作用和应用前景。1　药物研究的基本过程[1 ]用于防治疾病的药物 ,都必须是经过大量研究观…

Application of high throughput screening in drug development

The techniques used in the field of drug discovery have been quickly developed during the past decades High throughput screening (HTS) is a new technique in drug discovery with the characteristics of efficiency, huge scale and automatically operation The assay methods used in HTS are based on the molecular targets and cells Screening results obtained from these methods indicate not only the bioactivities of compounds (samples) but also the mechanisms of actions of the compounds (samples) HTS has altered the strategy of drug development