颈动脉粥样硬化斑块与同型半胱氨酸的相关性研究

目的探讨颈动脉粥样硬化斑块和同型半胱氨酸的相关性,为临床缺血性脑血管病防治方案的制定提供理论依据。方法选取我院收治的缺血性脑血管病患者126例,根据患者颈动脉彩色超声多普勒检查的结果,颈动脉稳定性斑块71例患者为A组,颈动脉不稳定性斑块的55例患者为B组。采集2组患者外周静脉血检测同型半胱氨酸水平并进行对比。结果 2组患者三酰甘油、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平对比,差异均无统计学意义（P〉0.05）;A组和B组患者的同型半胱氨酸水平分别为（19.52±5.71）、（33.61±6.51）μmol/L,2组比较差异有统计学意义（P〈0.05）。结论检测缺血性脑血管病动脉粥样硬化斑块患者同型半胱氨酸水平,有助于评估患者斑块的稳定性,指导临床的诊疗,预防急性脑血管事件的发生。

Research on the relationship between carotid atherosclerotic plaque and homocysteine

Objective To investigate the relationship between carotid atherosclerosis plaque and homocysteine,so as to provide theoretical evidence for the development of prevention and treatment protocol in patients with clinical ischemic cerebrovascular disease. Methods One hundred and twenty-six cases of ischemic cerebrovascular disease admitted into our hospital were selected as our study subjects. In accordance with the results of carotid artery color Doppler ultrasound detection,71 cases of stable carotid plaques were designated as group A,and 55 cases of unstable carotid plaques were designated as group B. Peripheral venous blood from the patients of both groups were collected for the detection of homocysteine levels and the results of detection were compared between the 2groups. Results There were no statistical differences in the levels of triglyceride,total cholesterol,low density lipoprotein cholesterol and high density lipoprotein cholesterol in the patients of both groups,when comparisons were made between them（ P〉0. 05）. The homocysteine level in the patients of group A was（ 19. 52 ± 5. 71） μ mol /L,and the homocysteine level in the patients of group B was（ 33.61 ± 6.51） μ mol/L. As seen from above,the homocysteine level in the patients of group B was significantly higher than that of the patients in group A（ P〈0. 05）. Conclusion Detection of homocysteine levels in the patients with the formation of atherosclerosis plaque in ischemic cerebrovascular disease was helpful to the evaluation of plaque stability,the diagnosis and treatment of the disease,and the prevention of the occurrence of acute cerebrovascular events as well.