| 雷米芬太尼靶控输注抑制全麻拔管期心血管不良反应的剂量探讨 |
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| 引用本文： | 乔世刚,谢红,李华,常留辉,傅志海,王琛.雷米芬太尼靶控输注抑制全麻拔管期心血管不良反应的剂量探讨[J].临床麻醉学杂志,2010,26(1). |
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| 作者姓名： | 乔世刚 谢红 李华 常留辉 傅志海 王琛 |
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| 作者单位： | 苏州大学附属第二医院麻醉科,苏州市,215004 |
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| 基金项目： | 苏州市社会发展项目(SSY0627) |
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| 摘 要： | 目的探讨雷米芬太尼靶控输注(TCI)拔管期有效抑制心血管反应的半数有效血浆浓度(EC50)。方法择期全麻下行腹腔镜胆囊切除术(LC)成人患者40例,按照序贯法TCI血浆浓度分别为0.6、0.8、1.0、1.2和1.4 ng/ml的雷米芬太尼,初始靶浓度为1.0 ng/ml,若患者拔管时SBP高于基础值的20%或HR快于100次/分,或拔管时出现呛咳、躁动,则下一例患者采用高一级浓度的雷米芬太尼TCI;反之则采用低一级浓度的雷米芬太尼TCI。计算全麻拔管期有效抑制心血管反应的雷米芬太尼EC50及其95%可信区间(CI)。结果TCI雷米芬太尼抑制心血管反应的EC50为1.03 ng/ml,其95%CI为0.97~1.09 ng/ml。结论LC全麻拔管期有效抑制心血管反应的雷米芬太尼EC50为1.03 ng/ml。
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| 关 键 词： | 雷米芬太尼 拔管期心血管反应 |
An investigation on EC_(50) of remifentanil for attenuating cardiovascular response to extubation |
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| QIAO Shi-gang,XIE Hong,LI Hua,et al..An investigation on EC_(50) of remifentanil for attenuating cardiovascular response to extubation[J].The Journal of Clinical Anesthesiology,2010,26(1). |
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| Authors: | QIAO Shi-gang XIE Hong LI Hua |
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| Institution: | QIAO Shi-gang,XIE Hong,LI Hua,et al.Department of Anesthesiology,Affiliated Second Hospital,Soochow University,Suzhou 215004,China |
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| Abstract: | Objective To determine the half-effective target plasma concentration(EC50) of remifentanil TCI for attenuating cardiovascular response to extubation.Methods Forty patients aged 18 to 60 years old undergoing selective laparoscopic cholecystectomy(LC) under general anesthesia.By up-and-down sequential trial,remifentanil in the target plasma concentrations of 0.6,0.8,1.0,1.2,and 1.4 ng/ml was infused.The initial plasma concentration was set at 1.0 ng/ml,a higher or lower TCI dose was selected if SBP or HR cha... |
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| Keywords: | Remifentanil Cardiovascular response to extubation |
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