| 氨苄青霉素的剂型和生物利用度研究 |
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| 引用本文： | 孔晓东,蔡玉珉. 氨苄青霉素的剂型和生物利用度研究[J]. 沈阳药科大学学报, 1986, 0(1) |
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| 作者姓名： | 孔晓东 蔡玉珉 |
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| 作者单位： | 沈阳药学院药剂教研室，沈阳药学院药剂教研室 |
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| 摘 要： | 利用紫外分光光度法测定志愿者投药后尿中氨苄青霉素浓度,同时采用隔室模型和矩分析两种方法评价了氨苄青霉素的药物动力学和生物利用度。结果表明氨苄青霉素无水物和三水合物生物利用度无显著性差异;国产氨苄青霉素酞酯与母体比较,生物利用度提高不明显;各种口服制剂(胶囊,片剂和糖浆剂)尿中回收给药量百分率均无显著性差异;直肠给药吸收很快,但生物利用度低于口服给药,静滴给药80%以上以原型由尿中排出。
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| 关 键 词： | 氨苄青霉素 氨苄青霉素水合物 氨苄青霉素酞酯 剂型 生物利用度 药物动力学 |
STUDY ON DOSAGE FORM AND BIOAVAILABILITY OF AMPICILLIN |
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| Kong Xiaodong Cai Yumin Pharmaceutical Department. STUDY ON DOSAGE FORM AND BIOAVAILABILITY OF AMPICILLIN[J]. Journal of Shenyang Pharmaceutical University, 1986, 0(1) |
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| Authors: | Kong Xiaodong Cai Yumin Pharmaceutical Department |
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| Affiliation: | Kong Xiaodong Cai Yumin Pharmaceutical Department |
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| Abstract: | The pharmacokinetics and bioavailability of Ampicillin were studied using urinary data in this paper.The drug concentration in the urine was determined using ultraviolet spectrophotometic method.It was shown that there was no difference in bioavailability between Ampicillin anhydrate and its trihydrate.The availability of Talampicillin was only a little higher than that of Ampicillin.The Ampicillin.excreted in urine had the same amount within 8 hours after oral administration of the same dose of tablet,capsule and syrup.the absorption rate were faster after rectal adminstration than oral.80% of the given dose was excreted in urine after iv infusion to patients. |
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| Keywords: | Ampicillin Hydrate Talampicillin Dosage form Pharmacoki netics Bioavailability |
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