不同剂量阿托伐他汀治疗高危老年患者对睡眠质量影响的对比研究(附140例报告)

目的探讨阿托伐他汀每日10mg或20mg对60～80岁血脂异常伴颈动脉内膜中层(IMT)增厚或斑块形成的老年患者睡眠质量的影响。方法睡眠质量变化采用卡方()分析,IMT变化采用重复测量设计的方差分析,将符合纳入标准的患者共140例入选后,每日分别给予阿托伐他汀10mg或20mg睡前服用,连续用药6个月,分别于用药前及治疗6个月后采用汉化匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)评价睡眠质量;同时测定生化指标及IMT变化。结果服用阿托伐他汀10mg或20mg治疗6个月后,两组组内前后比较PSQI得分差异无统计学意义(=0.216,P=0.975;=0.150,P=0.985),两组组间比较差异无统计学意义(=0.904,P=0.824;=1.109,P=0.775);双侧颈总动脉和颈动脉分叉处IMT组内比较差异有统计学意义(P<0.05,P<0.05)。结论阿托伐他汀在改善IMT的同时,未对睡眠产生影响。

Different doses of atorvastatin for treatment of high risk elderly patients comparison of the effects of sleep quality.With the report of 140 cases

Objective To evaluat atorvastatin 10 mg or 20 mg daily for 60 to 80 years of age and with carotid artery intima-media thickening(IMT) or plaque formation in elderly patients with sleep quality.Methods Changes in sleep quality approach using chi-square() analysis,IMT changes using repeated measures analysis of variance design,the patients met the inclusion criteria selected a total of 140 cases,the daily were given atorvastatin 10 mg or 20 mg at bedtime taking continuous medication in June,respectively,before treatment and 6 months after treatment finished using the Pittsburgh Sleep Quality Index(Pittsburgh sleep quality index,PSQI) evaluation of sleep quality;simultaneous determination of biochemical markers and IMT change.Results taking atorvastatin 10mg or 20mg after 6 months of treatment,both groups before and after no significant difference in PSQI scores(= 0.216,P= 0.975;=0.150,P= 0.985),two group differences between groups was not significant(=0.904,P= 0.824;=1.109,P= 0.775);both common carotid arteries and carotid bifurcation IMT group difference was significant(P<0.05,P<0.05).Conclusion Effect of atorvastation on the improvement of ITM at the same time,not to sleep effect.