| 龟板对脊髓损伤后脊髓雌激素α受体及其基因表达的影响 |
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| 引用本文： | 郑雨,陈东风,周健洪,黎晖,李伊为,邓汝东,张赛霞.龟板对脊髓损伤后脊髓雌激素α受体及其基因表达的影响[J].中国药房,2004,15(5):271-273. |
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| 作者姓名： | 郑雨 陈东风 周健洪 黎晖 李伊为 邓汝东 张赛霞 |
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| 作者单位： | 1. 汕头市中心医院药学科,汕头市,515031
2. 广州中医药大学解剖学教研室,广州市,510405 |
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| 基金项目： | 国家自然科学基金，广东省自然科学基金 |
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| 摘 要： | 目的 :观察龟板对脊髓损伤后脊髓雌激素α受体 (ER -α)及其基因表达的影响。方法 :以改良的Allen法建立大鼠脊髓损伤模型 ,随机分为对照组、模型组和龟板治疗组 ,用免疫组织化学和原位杂交方法检测脊髓中ER -α及其mRNA的表达。结果 :模型组中脊髓ER -α受体及其mRNA的阳性细胞数与对照组比较显著减少 ;治疗组中ER -α及其mRNA的阳性细胞数与模型组比较显著增加。结论 :龟板可增加脊髓损伤后脊髓ER -α及其基因的表达。
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| 关 键 词： | 龟板 脊髓损伤 雌激素α受体 雌激素α受体基因 运动神经元 |
| 文章编号： | 1001-0408(2004)05-0271-03 |
| 修稿时间： | 2004年4月28日 |
Effect of Plastrum Testudinis on the ER -αand Its mRNA in the Spinal Cord Following Spinal Cord Injury |
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| ZHENG YuDept.of Pharmacy,Shantou Central Hospital,Shantou CHEN Dongfeng,ZHOU Jianhong,LI Hui,LI Yiwei,DENG Rudong,ZHANG SaixiaDept.of Anatomy,Guangzhou University of Traditional Chinese Medicine,Guangzhou.Effect of Plastrum Testudinis on the ER -αand Its mRNA in the Spinal Cord Following Spinal Cord Injury[J].China Pharmacy,2004,15(5):271-273. |
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| Authors: | ZHENG YuDeptof Pharmacy Shantou Central Hospital Shantou CHEN Dongfeng ZHOU Jianhong LI Hui LI Yiwei DENG Rudong ZHANG SaixiaDeptof Anatomy Guangzhou University of Traditional Chinese Medicine Guangzhou |
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| Institution: | ZHENG YuDept.of Pharmacy,Shantou Central Hospital,Shantou515031 CHEN Dongfeng,ZHOU Jianhong,LI Hui,LI Yiwei,DENG Rudong,ZHANG SaixiaDept.of Anatomy,Guangzhou University of Traditional Chinese Medicine,Guangzhou510405 |
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| Abstract: | OBJECTIVE:To study the effect of Plastrum Testudinis on the ER-αand its mRNA in the spinal cord folˉlowing spinal cord injury.METHODS:The model was established with modified Allen spinal cord injury method.Rats were divided into three groups:the control group,spinal cord injury group,Plastrum Testudinis group.The changes of the ER-αand ER-αmRNA positive cells in the spinal cord was studied by immunohistochemistry and in situ hybridization.RESULTS:The number of ER-αand ER-αmRNA positive cells in the spinal cord motor neuron of the spinal cord injury group was less than that of the control group;Plastrum Testudinis increased the number of ER-αand ER-αmRNA positive cells in the spinal cord motor neuron of the spinal cord injury rats.CONCLUSION.Plastrum Testudinis could increase the expression of ER-αand ER-αmRNA in the spinal cord motor neuron to enhance estrogen neuroprotection activity. |
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| Keywords: | Plastrum Testudinis spinal cord injury estrogen receptor alpha estrogen receptor alpha mRNA motor neuron |
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