| 大鼠脑干5-羟色胺能上行和下行通路在针刺镇痛和吗啡镇痛中的作用 |
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| 引用本文： | 周保和,金文泉,刘佩丽.大鼠脑干5-羟色胺能上行和下行通路在针刺镇痛和吗啡镇痛中的作用[J].针刺研究,1981(2). |
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| 作者姓名： | 周保和 金文泉 刘佩丽 |
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| 作者单位： | 重庆医学院生理教研室，重庆医学院生理教研室，重庆医学院生理教研室 |
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| 摘 要： | <正> 关于针刺镇痛的原理,许多资料说明脑干中缝核系统在针刺镇痛中起重要作用,中缝核色胺能神经元轴突末梢的神经递质5-羟色胺(5-HT)是针刺镇痛的重要物质基础。中缝核神经元的轴突分布很广,其上行纤维经内侧前脑束(MFB)上达间脑和端脑各部,下行纤维广泛分布于脊髓的灰质,在脑干部分还与兰斑核,巨细胞核等其他网状结构神经核团有广泛联系.以往的工作证
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THE ROLE OF ASCENDING AND DESCENDING 5-HYDROXYTRYPTAMINERGIC PATHWAY OF THE RAT BRAIN STEM IN ACUPUNCTURE AND MORPHINE ANALGESIA |
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| Abstract: | Experiments were performed on adult female rats with tail-flick responseas the antinociceptive test.The effects of destruction of ascending 5-HTpathways by mechanical lesions of MFB were similar to these by specificchemical lesions with 5,6-DHT as formerly reported.The 5-HT and 5-HIAAcontents of the telencephalon and diencephalon were lowered markedly aswell as the effect of acupuncture and morphine analgesia.Intraspinal micro-injection of 5,6-DHT lowered selectively the 5-HT content of the spinalcord.It showed that the descending 5-HT pathways were destroyed in certaindegree.Under such condition,the effect of morphine analgesia were lower-red but the effect of acupuncture analgesia remains unchanged.The resultsof these experiments suggest that the ascending 5-HT pathways are moreimportant for acupuncture analgesia than descending 5-HT pathways butboth ascending and descending 5-HT pathways are necessary for morphineanalgesia. |
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