| 脑缺血后强制性运动疗法对内源性神经干细胞及基质细胞衍生因子-1水平的影响 |
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| 引用本文： | 赵传胜,戚其学,赵珊珊,翟志永.脑缺血后强制性运动疗法对内源性神经干细胞及基质细胞衍生因子-1水平的影响[J].中国血液流变学杂志,2007,17(4):521-524. |
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| 作者姓名： | 赵传胜 戚其学 赵珊珊 翟志永 |
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| 作者单位： | 1. 中国医科大学附属第一临床学院神经内科,辽宁沈阳,110001
2. 中国医科大学附属第一医院血液流变室,辽宁沈阳,110001 |
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| 基金项目： | 国家自然科学基金;教育部留学回国人员科研启动基金 |
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| 摘 要： | 目的目前强制性运动疗法广泛地应用于康复领域,并被证实能够有效地促进肢体功能恢复,但其确切的机制尚不清楚。方法应用免疫组化及ELISA方法并结合行为学探讨了强制性运动疗法对脑缺血后内源性神经干细胞及间质细胞源性因子-1表达的影响。结果发现脑缺血后强制性运动疗法能够促进患侧肢体运动功能的恢复,增加大鼠侧脑室下区新生神经干细胞的数量,并能提高脑组织基质细胞衍生因子-1蛋白的表达水平。结论强制性运动疗法可能通过影响脑缺血后的神经再生过程从而达到增强中枢神经系统修复能力的作用。
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| 关 键 词： | 脑缺血 强制性运动疗法 神经干细胞 基质细胞衍生因子-1 |
| 文章编号： | 1009-881X（2007）04-0521-04 |
| 收稿时间： | 2007-09-09 |
| 修稿时间： | 2007年9月9日 |
The Effects of Constraint-induced Movement Therapy on the Regulation of Endogenous Neural Stem Cells and the Expression of Stromai Cell-derived Factor 1 |
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| ZHAO Chuan-sheng,QI Qi-xue,ZHAO Shan-shan,ZHAI Zhi-yong.The Effects of Constraint-induced Movement Therapy on the Regulation of Endogenous Neural Stem Cells and the Expression of Stromai Cell-derived Factor 1[J].Chinese Journal of Hemorheology,2007,17(4):521-524. |
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| Authors: | ZHAO Chuan-sheng QI Qi-xue ZHAO Shan-shan ZHAI Zhi-yong |
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| Institution: | 1.Department of Neurology;2.Hemorheology Laboratory,First Clinical College,China Medical University, Shenyang 110001 |
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| Abstract: | Objective Constraint-induced movement therapy(CIMT)is effective to improve the func-tional recovery after stroke.Method This study investigated the effects of CIMT on the regulation of endogenous neural stem cells and the expression of stromal cell-derived factor 1(SDF-1) using immunohistochemistry and ELISA combined with behavioral tests.Results Following stroke,CIMT can improve the functional recovery,increase the number of neural stem cells in subventricular zone and increase the level of stromal cell-derived factor 1 protein.Conclusion CIMT may enhance the self-repair of central nervous system by stimulating the neurogenesis after stroke. |
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| Keywords: | stroke constraint-induced movement therapy neural stem cell stromal cell-derived factor 1 |
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