膀胱尿路上皮癌MRP-1/CD9和cyclinD1的表达与肿瘤生物学行为的关系

目的:探讨MRP-1/CD9和cyclinD1的表达与膀胱尿路上皮癌生物学行为的关系。方法:应用免疫组化法检测80例膀胱尿路上皮癌组织和12例正常对照组膀胱组织MRP-1/CD9和cyclinD1的表达情况。结果:MRP-1/CD9阳性表达率膀胱癌组为51.25%,对照组为91.11%(P<0.05);Ta～T1肿瘤阳性表达率为71.42%,T2～T4为35.56%;G1肿瘤阳性表达率为78.57%,G2为43.48%,G3为31.03%,随着肿瘤浸润性和分级上升,阳性表达率逐渐下降(P<0.01,P<0.05);MRP-1/CD9阳性表达率肿瘤初发和复发者之间差异无统计学意义(P>0.05);肿瘤单发者高于多发者(P<0.05)。膀胱尿路上皮癌cyclinD1阳性表达率为53.75%,对照组为0(P<0.01);Ta～T1肿瘤阳性表达率为78.57%,T2～T4为17.65%;G1肿瘤阳性表达率为85.71%,G2为56.52%,G3为20.69%,随着肿瘤浸润性和分级升高,cyclinD1阳性表达率逐渐降低(P<0.05,P<0.05)。cyclinD1阳性表达率肿瘤初发和复发者、多发者和单发者之间差异无统计学意义(P>0.05,P>0.05)。结论:MRP-1/CD9表达与膀胱尿路上皮癌的浸润性和分级相关,其表达缺失可能是判断该肿瘤预后的一个指标;cy-clinD1较能准确地评估膀胱尿路上皮癌的生物学行为,二者对于判断膀胱癌的预后有重要的临床意义

Ralativity of MRP-1/CD9 and cyclinD1 expression in bladder urothelial carcinoma and tumor biological behavior

Objective:This study was to explore the expression and significance of cyclinD1 and MRP-1/CD9 in bladder urothelial carcinoma.Methods:MRP-1/CD9and cyclinD1 expression of 80 cases of bladder urothelial carcinoma and 12 normal control bladder tissue was detected by immunohistochemical technique.Results:The positive expression rate of MRP-1/CD9 in bladder cancer bladder was 51.25% in the control group 91.11%(P<0.05).Ta-T1 tumors positive rate was 71.42%,T2-T4 was 35.56%.G1 tumors positive expression rate was 78.57%,G2 was 43.48%,G3 was 31.03%.with increased tumor invasive and grade,the positive expression rate decreased(P<0.01,P<0.05).MRP-1/CD9 positive expression rate of tumor onset and recurrence was no significant difference(P>0.05),and multiple lesions were greater than singular lesions(P<0.05).Bladder urothelial carcinoma cyclinD1 positive expression rate of 53.75% in the control group 0(P<0.01).Ta-T1 tumors positive rate was 78.57%,T2-T4 was 17.65%,G1 tumors positive expression rate was 85.71%,G2 was 56.52%,G3 was 20.69%.With the increase in tumor invasive and grade,cyclinD1 positive rate decreased(P<0.01,P<0.05).cyclinD1 positive rate of tumor onset and recurrence of tumor,multiple and single were no statistically significant difference(P>0.05,P>0.05).Conclusions:In patients with urothelial bladder carcinoma,MRP-1/CD9 expression was associated significantly with tumor invasive and grade,and a loss of MRP-1/CD9 expression was an prognostic factor for predicting progression in patients with urothelial bladder carcinoma.cyclinD1 may be a more accurate assessment of bladder urothelial carcinoma of the biological behavior.The detection of the expression of MRP-1/CD9 and cyclinD1 is in favor of diagnosis and prognostic evaluation of bladder cancer.