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黄连素对2型糖尿病(湿热内蕴型)胰岛β细胞功能的影响
引用本文:刘红樱,胡齐鸣.黄连素对2型糖尿病(湿热内蕴型)胰岛β细胞功能的影响[J].中国中医药信息杂志,2008,15(3):12-14.
作者姓名:刘红樱  胡齐鸣
作者单位:1. 江西中医学院,江西,南昌,330006
2. 江西中医学院附属医院,江西,南昌,330006
摘    要:目的观察黄连素对2型糖尿病(湿热内蕴型)胰岛β细胞功能的影响。方法随机选取2型糖尿病中医辨证属湿热内蕴型患者60例,分为对照组和试验组,每组各30例,应用二甲双胍作为基础治疗,2周后试验组加用黄连素,总疗程8周。观察试验前后各组的血糖、胰岛素、糖化血红蛋白、C反应蛋白及中医证候总分和单项症状评分的变化;应用胰岛素敏感性指数(IAI)、胰岛素抵抗指数(HOMA-IR)、β细胞分泌指数(HOMA-β)计算胰岛β细胞功能的改善情况。结果2组在试验前后各指标均有显著变化(P〈0.05),以试验组的指标改善为明显,2组之间比较有显著差异(P〈0.05),试验组的胰岛β细胞功能改善最为明显。结论黄连素具有明显的改善胰岛β细胞功能、促进胰岛素的分泌及减轻胰岛素抵抗和增加胰岛素敏感性的作用。

关 键 词:2型糖尿病  黄连素  湿热内蕴型  胰岛β细胞功能
文章编号:1005-5304(2008)03-0012-03
修稿时间:2007年6月11日

Effect of Berberine on Islet β-cell Function in Type 2 Diabetes Mellitus(Damp-Heat Type)
LIU Hong-ying,HU Qi-ming.Effect of Berberine on Islet β-cell Function in Type 2 Diabetes Mellitus(Damp-Heat Type)[J].Chinese Journal of Information on Traditional Chinese Medicine,2008,15(3):12-14.
Authors:LIU Hong-ying  HU Qi-ming
Institution:LIU Hong-ying1, HU Qi-ming2(1.Jiangxi College of TCM, Nanchang 330006, China;2.The Affiliated Hospital of Jiangx College of TCM, Nanchang 330006, China)
Abstract:Objective To observe the effect of berberine to islet β-cell function in type 2 diabetes mellitus (damp-heat type). Methods 60 patients with type 2 diabetes mellitus (damp-heat type) were randomly divided into 2 groups, under basic treatment of 2 weeks with mefformin, the treatment group was given berberine. After 8 weeks, the changes in the levels of blood glucose, insulin, HbAlc, CRP and the grade of traditional Chinese medicine individual event symptom and general integral symptom were observed. Apply the formular to evaluate the pancreas's function. Results Each group had notable difference before and after the experiment in many aspects, especially in treatment group. There was a notable difference in 2 groups. Conclusion Berberine has obvious effect on increasing insulin releasing level, improving insulin sensibility, lightening insulin resistance and improving islet β-cell function.
Keywords:type 2 diabetes mellitus  berberine  damp-heat type  islet β-cell function
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