| 替卡西林钠的合成新工艺 |
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| 引用本文： | 郭剑虹,周改平,李祖文.替卡西林钠的合成新工艺[J].山西临床医药,2012(11):841-843. |
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| 作者姓名： | 郭剑虹 周改平 李祖文 |
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| 作者单位： | 山西博康药业有限公司,山西太原030021 |
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| 摘 要： | 目的：制备替卡西林钠。方法：以3-噻吩丙二酸为起始原料,经过酰氯化、酰胺化、成盐反应制得替卡西林单钠。替卡西林单钠与碳酸氢钠在水溶液中反应后,真空冷冻干燥制得替卡西林钠。结果：总收率62.8%,含量〉98.0%。结论：该方法制备的替卡西林钠收率高,质量好,易于实现工业化。
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| 关 键 词： | 替卡西林 化学合成 3-噻吩丙二酸 抗生素 |
New process for the synthesis of ticarcillin disodium salt |
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| GUO Jian-hong,ZHOU Gai-ping,Li Zu-wen.New process for the synthesis of ticarcillin disodium salt[J].Shanxi Clinical Medicine,2012(11):841-843. |
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| Authors: | GUO Jian-hong ZHOU Gai-ping Li Zu-wen |
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| Institution: | (Shanxi Guardian Pharmaceuticals Company Limited,Taiyuan 030021,China) |
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| Abstract: | Objective：To prepare ticarcillin disodium salt.Methods：The objective compound was synthesized from ticarcillin sodium by salted with sodium bicarbonate and then through freeze-drying.Ticarcillin sodium was prepared from 3-thiophene malonic acid by acylchloride,amidation and salted with 2-ethylhexanoate sodium.Results：Qverall yield was 62.8% and assay was exceeding 98.0%.Conclusion：Ticarcillin disodium salt prepared by this method which was obtained with high yield and good quality.In addition this method was suitable for commercial production scales. |
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| Keywords: | ticarcillin chemical synthesis 3-thiophene malonic acid antibiotics |
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