庚型肝炎病毒抗体在不同人群中的检测及意义

为了解庚型肝炎病毒(GBV-C/HGV)在我国人群的感染状况,应用ELISA法对277例各种肝病及103例肝炎高危人群血清进行了抗-GBV-C/HGV-IgG的检测。结果:急性肝炎、慢性肝炎、重型肝炎、肝炎肝硬变和肝癌患者抗-GBV-C/HGV检出率分别为20.3％(13/64)、15.6％(19/122)、26.7％(12/45)、28.2％(11/39)和28.6％(2/7);在HAV、HBV、HCV、HAV+HBV、HBV+HCV、HBV+HDV和HAV+HBV+HCV肝炎病人中检出率分别为15.6％(5/32)、26.1％(31/119)、20.7％(6/29)、26.1％(6/23)、28.6％(4/14)、18.2％(2/11)、33.3％(1/3)和在非甲-戊型肝炎中的检出率为12.1％(4/33);献血员、血液透析者、静脉毒瘾者抗-GBV-C/HGV检出率分别为14.7％(5/34)、6.3％(2/32)和8.1％(3/37),以上结果组间均无显著差异(P>0.05)。研究表明,在我国部分肝病及肝炎高危人群中存在庚型肝炎病毒感染,GBV-C/HGV与HAV、HBV、HCV、HDV之间存在多种形式的同时或重叠感染,非甲-戊型肝炎中存在GBV-C/HGV感染,但感染率并不高,提示GBV-C/HGV可能是非甲-戊型肝炎的一种病原体,但并非是非甲-戊型肝炎的主要致病因子。

DETECTION OF SERUM ANTI - GBV - C/HGV IN HUMAN GROUPS WITH OR HIGHLY SUSCEPTIBLE TO VIRAL HEPATITIS

In order to invesgitate the infection states of GBV-C/HGV" in various human groups, the EL1SA method was taken to detect serum anti-GBV-C/HGV in 277 patients with various kinds of hepati tis.It was found that the positive rates of serum anti-GBV-C/HGV in patients with acute hepatitis, chronic hepatitis, severe hepatitis, liver cirrhosis and hepatocellular carcinoma were 20.3% ( 13/64), 15.6%(19/122),26.7%(12/45),28.2%(11/39) and 28.6% (2/7), respectively.The positive rates of serum anti-GBV-C/HGV in HA, HB, HC, HA + HB, HB + HC, HB + HD and HA + HB + HC hepatitis patients were 15.6% (5/32),26.1 % (31/119) ,20.7% (6/29), 26.1 % (6/23), 28.6% (4/ 14),18.2%(2/11) and 33.3% ( 1/3), respectively.It was 12.1%(4/33) in non A-E hepatitis, 14.7%(5/34) in healthy blood donors,6.3% (2/32) in patients on hemodialysis and 8.1%(3/37) in intravenous drug addicts.The results showed that GBV-C/HGV infection existed in patients with various hepatic diseases and human groups at high risk of hepatitis in our country.There was a high tendency of various kinds of coinfection or superinfection for HGV with other hepatotropic viruses such as HAV,HBV,HCV or HDV.There existed GBV-C/HGV infection in non A-K hepatitis, hut the anti-GBV-C/HGV positive rate in aon A-E hepatitis was not high, It indicates that the GBV-C/ HGV may be an agent of non-A-E hepatitis,but not a dominant one.