内镜超声引导下胰腺病灶细针穿刺抽吸术的安全性分析

目的 探讨胰腺病灶内镜超声引导下细针穿刺抽吸术(EUS-FNA)的安全性.方法 选择2005年1月至2007年6月间行胰腺EUS-FNA的患者,记录并发症情况,结合文献资料,分析可能的相关危险因素.结果 总共119例患者行胰腺EUS-FNA,其中1例出现术后急性轻症胰腺炎,经治疗后治愈,9例患者(7.6%)术后3 h出现高淀粉酶血症,血淀粉酶197～835 U/L,平均(327±200)U/L,6例(5.0%)患者术后24 h血淀粉酶仍持续升高.经Logistic回归分析发现既往急性胰腺炎病史、性别、穿刺针大小及穿刺针数、囊性病灶、术前血淀粉酶值以及病灶部位可能均不是高淀粉酶血的危险因素.结论 胰腺EUS-FNA术后总的并发症发生率较低,是一项安全的操作技术.

Safety analysis of endoscopic ultrasound-guided fine needle aspiration of pancreatic lesions

Objective To assess the safety of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)of pancreatic lesions.Methods Patients who underwent EUS-FNA of a pancreatic lesion between January 2005 and June 2007were studied retrospectively.Possible risk factors were assessed by using logistic analysis.Results In 119 patients who underwent pancreatic EUS-FNA,mild acute pancreatitis were observed in 1(0.84%)patient after the operation.No complication occurred in 12 patients with regional portal vein hypertension.Nine patients(7.6%)showed hyperamylasemia 3 h after the procedure,rangeing from 197 to 835 U/L,with an average of(327±200)U/L.Blood amylase level kept increasing 24 h postoperatively in 6 cases of the 9.Logistic regression analysis showed past history of acute pancreatitis,gender,needle size,number of puncture,cystic foci,preoperative blood amylase level and location of foci would not possibly be the risk factors of hyperamylasemia.Conclusion Incidence of complications after EUS-FNA is 0.84%,and the occurrence rate of hyperamylasemia is 7.6%,indicating,EUS-FNA is a safe procedure.