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Acute Oxalate Nephropathy Causing Late Renal Transplant Dysfunction Due to Enteric Hyperoxaluria |
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| Authors: | A. C. Rankin S. B. Walsh S. A. Summers M. P. Owen M. A. Mansell |
| Affiliation: | Renal Department, King's College London School of Medicine, London, UK;Centre for Nephrology and Department of Physiology, Royal Free &University College Medical School, Rowland Hill Street, London, UK;Centre for Inflammatory Disease, Department of Medicine, Monash University, Melbourne, Australia;Department of Histopathology, Royal London Hospital, Whitechapel, London, UK;The Centre for Nephrology, Royal Free Hospital, London, UK |
| Abstract: | Calcium oxalate (CaOx) deposition in the renal allograft is an under recognized and important cause of acute tubular injury and early allograft dysfunction. We present a case of late transplant dysfunction due to acute oxalate nephropathy. The patient presented with diarrhea and deteriorating graft function, and a diagnosis of enteric hyperoxaluria secondary to pancreatic insufficiency was made. This had occurred, as the patient had been noncompliant with his pancreatic enzyme replacement therapy. Treatment to reduce his circulating oxalate load was initiated, including twice-daily hemodialysis, low fat and oxalate diet and appropriate administration of pancreatic enzyme supplements. Graft function subsequently recovered. The possibility of fat malabsorption leading to enteric hyperoxaluria should be considered in renal graft recipients presenting with loose stools and graft dysfunction. |
| Keywords: | Acute oxalate nephropathy diarrhea enteric hyperoxaluria fat malabsorption renal allograft renal allograft dysfunction |