拉米夫定和补肾方联合应用治疗慢性乙型肝炎的疗效及对YMDD区域的影响

目的：观察拉米夫定和补肾方联合应用治疗慢性乙型肝炎的疗效及对慢性乙型肝炎病毒P基因酪氨酸—蛋氨酸—天冬氨酸—天冬氨酸(YM)D)区域的影响。方法：收集乙型肝炎病毒(HBV)DNA阳性的慢性乙型肝炎患者88例，分为拉米夫定组、拉米夫定加补肾方l组和拉米夫定加补肾方2组共3组，分别检测血清HBV DNA、肝脏生化指标和P基因YMDD区域变异。结果：在治疗52周时，拉米夫定加补肾方2组无论是HBV DNA阳性率(6．45％)，还是YMDD变异率(3．23％)都比拉米夫定组低。结论：初步表明，拉米夫定与补肾方联合用药能在一定程度上提高治疗慢性乙型对炎的疗效，并可能减少YMDD的变异。

Therapeutic Efficacy of Combined Application of Lamivudine and Bushen Recipe in Treating Chronic Hepatitis B and Its Influence on YMDD Motif

Objective: To observe the effect of combined application of Lamivudine and Bushen recipe (BSR) in treating patients with chronic hepatitis B(CHB) and its influence on tyrosine-methionine-aspartate-aspartate (YMDD) motif. Methods: Eighty-eight patients of CHB with positive HBV-DNA were divided into 3 groups, Group A treated with Lamivudine, Group B treated with Lamivudine plus BSR1 and Group C treated with Lamivudine plus BSR2, the serum HBV-DNA, hepatic biological parameters and YMDD motif mutation were observed. Results: The positive rate of HBV-DNA (6.45 % ) and YMDD motif mutation (3.23 % ) in Group C were lower than those in Group A respectively, after 52 weeks treatment. Conclusion: Combined application of Lamivudine and BSR could enhance the therapeutic effect in treating CHB to certain extent, and could reduce the mutation of YMDD motif.