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Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice |
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| Authors: | S. M. Turpin A. J. Hoy R. D. Brown C. Garcia Rudaz J. Honeyman M. Matzaris M. J. Watt |
| Affiliation: | (1) Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Wellington Rd, Clayton, Victoria, 3800, Australia;(2) St Vincent’s Institute of Medical Research and the Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia; |
| Abstract: | Aims/hypothesisHepatic steatosis is characterised by excessive triacylglycerol accumulation and is strongly associated with insulin resistance. An inability to efficiently mobilise liver triacylglycerol may be a key event mediating hepatic steatosis. Adipose triacylglycerol lipase (ATGL) is a key triacylglycerol lipase in the liver and we hypothesised that liver-specific overproduction of ATGL would reduce steatosis and enhance insulin action in obese rodents. |
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