| 熔融法制备对乙酰氨基酚缓释微丸 |
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| 引用本文： | 唐翠,王洪光,张汝华.熔融法制备对乙酰氨基酚缓释微丸[J].中国医药工业杂志,2000,31(1):12-14. |
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| 作者姓名： | 唐翠 王洪光 张汝华 |
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| 作者单位： | 复旦大学生命科学学院!上海200433(唐翠)，沈阳药科大学!辽宁沈阳110015(王洪光，张汝华) |
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| 摘 要： | 采用熔融法制备了对乙酰氨基酚缓释微丸。分别用正交设计和多元回归分析的方法考察了影响药物释放的工艺因素和处方因素,通过改变制丸次数和处方中固体石蜡、单硬脂酸甘油酯、预胶化淀粉的用量等,可得到体外具较理想释药行为的对乙酰氨基酚缓释微丸。
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| 关 键 词： | 熔融法 缓释微丸 对乙酰氨基酚 |
| 修稿时间： | 1999-03-23 |
Preparation of Paracetamol Sustained Release Pellets with Melt Method |
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| Authors: | TANG Cui WANG Hong- Guang ZHANG Ru- Hua |
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| Institution: | TANG Cui1,WANG Hong- Guang2,ZHANG Ru- Hua2 |
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| Abstract: | Paracetamol sustained release pellets were prepared using melt method.The orthogonal design table L4( 2 3) and multiple stepwise regression analyses were used to investigate factors influencing the process and formulation on drug release.By means of changing granulating times and the amounts of paraffin,glyceryl monostearate and pregelatinized starch,paracetamol sustained release pellets with the ideal release behavior in vitro were obtained. |
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| Keywords: | meltmethod sustained release pellets paracetamol preparation |
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