急性胰腺炎治疗的实验研究

严重急性胰腺炎(SAP)由于全身炎性反应综合征导致多器官衰竭而引起较高的病死率。至今,除了支持性重症监护疗法之外还没有治疗SAP的有效方法。为降低病死率,一些新的药物应用于实验性胰腺炎。最常用于实验研究的急性胰腺炎(AP)动物模型有三种,即蛙皮素、牛磺酸钠和无胆碱而乙硫氨酸充足的饮食(CDE)引起的水肿性或出血性胰腺炎。本文依据不同模型复制方法,对近年来实验治疗或取得的结果进行综述。许多方法包括蛋白酶抑制剂,抗炎性因子治疗,超氧化物治疗,核因子κB抑制剂治疗,血管加压素治疗,高压氧治疗等,已经显示出抗胰腺炎的保护作用。

Experimental Therapy of Acute Pancreatitis

Severe acute pancreatitis(sap) is a life-threatening disease with high morbidity and mortality due to multitipe organ failure induced by systemic inflammatory reaction syndrome.Up to now,there is no effective treatment for SAP other than supportive intensitive care therapy.Attempting to reduce the mortality rate,some new drugs have been investigated on experimental pancreatitis.There are mainly three animal models for the experimental reserash of AP.They are cerulean,Na-taurocholic acid and CDE-diet induced edematous or necrotizing pancreatitis.This paper is a review of the results of experimental therapy or procedure in recent years with different models.Many preparations and measures,including protease inhibitor,anti-inflammatory cytokine therapy,superoxide scavenger,cell-permeable nuclear factor-kappaB inhibitor,vasoactive agent,hyperbaric oxygen therapy ect,has really showed certain protective effect against SAP.