| 抗氧化剂对铅毒防治的作用及机制探讨 |
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| 引用本文： | 郭碧花,张星海. 抗氧化剂对铅毒防治的作用及机制探讨[J]. 中国工业医学杂志, 2004, 17(2): 100-104 |
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| 作者姓名： | 郭碧花 张星海 |
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| 作者单位： | 1. 西华师范大学生物系,四川,南充,637002
2. 浙江经贸职业技术学院应用生物系,浙江,杭州,310012 |
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| 摘 要： | 铅毒是世界范围内的公害，过去主要采用螯合剂治疗铅毒；由于铅离子可以加剧自由基对细胞的损伤，因此，采用抗氧化剂作为防治铅中毒的辅助疗法已成为大家关心的课题。本文主要综述维生素C和维生素E、蛋氨酸、乙酰半胱氨酸、硫辛酸、硒、锌、牛黄酸、茶叶提取物等抗氧化剂在铅中毒防治中的作用以及有关铅引起细胞氧化损伤的机制。
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| 关 键 词： | 抗氧化剂 铅中毒 预防 治疗 维生素C 维生素E 蛋氨酸 细胞氧化损伤 |
| 文章编号： | 1002-221X(2004)02-0100-05 |
| 修稿时间： | 2002-11-14 |
Studies on the effects of antioxidant agents on prevention and treatment of lead poisoning and its mechanism |
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| GUO Bi-hua ,ZHANG Xing-hai. Studies on the effects of antioxidant agents on prevention and treatment of lead poisoning and its mechanism[J]. Chinese Journal of Industrial Medicine, 2004, 17(2): 100-104 |
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| Authors: | GUO Bi-hua ZHANG Xing-hai |
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| Affiliation: | GUO Bi-hua 1,ZHANG Xing-hai 2 |
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| Abstract: | Lead pollution is a serious public hazard all over the world.In the past,lead poisoning was mainly treated with chelating agents.As lead ion could aggravate injury of free radicals to cells,therefore,supplementary therapy with anti-oxidant agents in prevention and treatment for lead poisoning has been become public concerns.Effects of anti-oxidant agents,such as vitamin C,vitamin E,methionine,ethylcysteine,lipoic acid,selenium,zinc,taurine,tea extract,etc.,in prevention and treatment for lead poisoning and mechanism of lead-related injury in cell oxidation are reviewed in this paper. |
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| Keywords: | Lead poisoning Anti-oxidant agent Chelating agent |
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