抑癌因子PTEN在喉鳞癌组织中的表达

目的: 观察喉鳞状细胞癌组织中与张力蛋白同源第10q23.3染色体丢失的磷酸酶基因(PTEN)的表达,探讨PTEN在喉鳞状细胞癌中的作用. 方法: 收集喉鳞状细胞癌标本41例(其中有淋巴结转移者11例)和20例正常软腭黏膜组织,用免疫组织化学染色法探测PTEN的表达情况. 结果: 喉鳞状细胞癌中PTEN表达阳性率为58.54%(24/41),显著低于正常软腭黏膜组织阳性率90%(18/20),PTEN在喉鳞状细胞癌中阳性率与淋巴结转移有关(P<0.05),未见与组织分化、临床分期和年龄相关(P>0.05).结论: PTEN在喉鳞状细胞癌组织中的低度表达在喉鳞状细胞癌发展中可能起重要作用.

Expression of PTEN in Laryngeal Squamous Cell Cacinoma

Objective: To detect the role of phosphatase and tensen-homology deleted on chromosome ten(PTEN) in laryngeal squamous cell carcinoma through observing the expression of PTEN in laryngeal squamous cell carcinoma.Methods: 41 cases of laryngeal squamous cell cacinoma(disease group) including 11 cases with lymph node metastasis,and 20 samples of normal soft palate mucosa(control group) were chosen and expression of PTEN were detected by immunohistochemistry.Results: PTEN expressed in 24 cases of laryngeal squamous cell cacinoma(58.54%) and in 18 cases of normal soft palate tissue(90%).The positive rate was lower in disease group than that in control group.The PTEN expression was significantly associated with lymph node metastasis status(P<0.05) but not with histological differentiation,clinical stage or patient age(P>0.05).Conclusions: The reduction of PTEN expression in laryngeal squamous cell cacinoma may play an important role in the development of laryngeal squamous cell cacinoma.