Detection of high risk pregnancies with relation to ABO haemolytic disease of newborn

IgM and IgG anti A and anti B antibody status of 100 antenatal O group mothers (who had non O group husbands) were studied. Of these, 3 mothers had an IgM anti A antibody levels ranging from 1 : 512 to 1 : 2048 and IgG ranging from 1 : 1204 to 1 : 2048, IgM anti B ranging from 1 : 128 to 1 : 512 and IgG anti B ranging from 1 : 256 to 1 : 512. All these mothers had A + ve children and all these children suffered from ABO haemolytic disease of newborn (HDN). A 4th mother had an IgM anti A titre of 1 : 64 and IgG anti A titre of 1 :16. The titre of IgM anti B in this mother was 1 : 512 and that of IgG 1 : 1024. The child was A + ve and did not suffer from ABO haemolytic disease of newborn.