不良暴露与妊娠结局关系的研究

目的探讨不良妊娠结局的发生率，分析孕早期相关危险因素与妊娠结局的关系。方法应用队列研究的方法，对入选对象追踪随访，随访方式为电话随访，随访终点为有妊娠结局发生，对相关因素进行卡方检验和Logistic回归分析。结果队列研究的结果显示，不良结局的发生率为9．64％，其中前3位的是：自然流产（3．3％）、人工流产（2．4％）、胎死官内（1．9％）。均衡各种因素后，情绪改变和被动吸烟是与不良妊娠结局相关的危险因素，而教育、TORCH感染等其他因素则未见显著关联。结论研究表明本地不良妊娠结局的发生率与其它地区接近，对不良妊娠结局的监测和预防工作的重点可以着眼于自然流产、人工流产和胎死宫内。应重视营造无吸烟的妊娠环境，加强孕妇家庭成员被动吸烟和主动吸烟同样有害的意识教育。适当缓解孕妇孕期的暴躁、紧张情绪，正确对待孕期生理和心理改变，有助于避免不良妊娠结局的发生。

Cohort Study on the Relation between Adverse Exposed Factors and Pregnancy Outcomes

Objective Tostudy relative risk factors for adverse pregnancyoutcomes.Methods Historicalcohort study was appliedto explore the relativeexposure factors for adverse pregnancyoutcomes.Chi-square test and logistic regression was the main analysismethod.Results: The mortalityof adverse pregnancyoutcomes was 9.64%.Spontaneous abortion,induced abortion and IUFD were the main adverse pregnancyoutcomes.Conditional logistic regression showed that mood and passive smoking were risk factors;there was no association between adverse pregnancyoutcomes and education or TORCH infections.Conclusion The mortality of adverse pregnancy outcomes was assimilated with other area.Maternal health care must focus to Spontaneousabortion,induced abortion and IUFD;helpful to construct nonsmoking environmentand release unusual mood of maternal.