经球囊超声导管消融对肺静脉的电隔离作用——附一只犬的动物实验报告

试研究球囊超声导管消融能否电隔离肺静脉、是否造成肺静脉的急性或者慢性狭窄。报告 1只犬的左上肺静脉经球囊超声导管消融电隔离结果。经房间隔将球囊超声导管的球囊置于左上肺静脉与左房的交界处 ,消融至电隔离。消融前后行肺静脉造影检查 ,2个月后行病理检查。结果 :消融开始至隔离的时间为 1160s。有效消融表现为肺静脉内的A波振幅逐渐降低 ,SP间期的逐渐延长至出现肺静脉与心房的电隔离。消融前与消融后 15min的造影对比 ,无肺静脉的狭窄及血液动力学变化。 2个月后尸体解剖发现肺静脉壁的轻度环行增厚 ,无左上肺静脉的狭窄。结论 :球囊超声消融可完全电隔离肺静脉 ,不造成肺静脉的急性或慢性狭窄 ,但长期效果仍有待观察。

The Effect of Electrical Isolation on Pulmonary Veins With Through-the-Balloon Ultrasound Ablation:One Dog Experimental Study Report.

To study whether ablation with Through-the-Balloon Ultrasound Ablation (TTB-USA) can electrically isolate left superior pulmonary vein (LSPV) and cause acute or chronic LSPV stenosis after ablation,the LSPV of one dog was electrically isolated with TTB-USA.Through the atrial septum,the TTB-USA was positioned at junction of LSPV and left atrium,and then begin to ablate to electrical isolation.Before,after ablation LSPV angiography was performed,and 2 months later pathological examination was made. Result: The total ablation time was 1160 seconds. The effective ablation was indicated by the gradual decrease of amplitude of A wave in pulmonary vein,the extension of SP interval and eventually the electrical isolation.No acute pulmonary vein stenosis was found before or after 15 min ablation.No hemodynamic change appeared after ablation. Tow months later, pathological examination of pulmonary vein showed the wall of LSPV became mild thicker circularly and no any stenosis in LSPV was found. Conclution: The TTB-USA can electrically isolate LSPV of dog and do not cause acute or chronic stenosis after ablation.