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HLA genotypes in two three-generation families with rheumatoid arthritis |
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| Authors: | H kan Str m, Solbritt Rantap Dahlqvist, Anders Bjelle,Erna M ller |
| Affiliation: | a Department of Internal Medicine, Division of Rheumatology, Danderyd Hospital, Sweden b Department of Clinical Immunology, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden c Departments of Rheumatology, Umeå University Hospital, Sweden d Sahlgren University Hospital, Gothenburg, Sweden |
| Abstract: | Two three-generation families from Northern Sweden with rheumatoid arthritis (RA) were clinically examined. Tissue typing was performed for HLA-A, -B, -C, and -DR antigens. No disease-associated haplotype could be defined within these families. Six of nine members with RA were HLA-DR4 positive. Both families had a HLA-DR4 containing haplotype in the first generation and second-generation members married DR4 positive individuals, which probably increased the risk to develop RA in the third-generation members. |
| Keywords: | RA rheumatoid arthritis MLC mixed lymphocyte culture ESR erythrocyte sedimentation rate H-Y H-Y antigen, the Y-linked testis-determining gene product of mammals RF rheumatoid factor ANA antinuclear antibodies |
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