| 四逆汤对失血性休克大鼠心功能和血压调节的肾上腺素受体机制研究 |
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| 引用本文： | 邵春红,王晓良.四逆汤对失血性休克大鼠心功能和血压调节的肾上腺素受体机制研究[J].中国药学杂志,2003,38(11):847-850. |
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| 作者姓名： | 邵春红 王晓良 |
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| 作者单位： | 中国医学科学院-中国协和医科大学药物研究所药理室,北京,100050 |
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| 基金项目： | 北京市自然科学基金项目 (No .70 110 0 2 ) |
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| 摘 要： | 目的观察四逆汤对失血性休克大鼠心功能的保护作用及其机制探讨。方法以血流动力学为指标，观察四逆汤对失血性休克大鼠的治疗作用,及α和β受体阻断剂对其作用的影响。结果四逆汤能改善失血性休克大鼠的左心室收缩压(LVSP)、左心室等容期压力最大变化速率(±dp/dtmax)和平均动脉压(MAP)的降低，α和β受体阻断剂可不同程度地阻断四逆汤对失血性休克大鼠的保护作用。结论四逆汤对失血性休克大鼠有强心、升压作用，其作用机制可能与调节肾上腺素α和β受体有关。
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| 关 键 词： | 四逆汤 血流动力学 α受体阻断剂 β受体阻断剂 |
| 文章编号： | 1001-2494(2003)11-0847-04 |
| 收稿时间： | 2002-10-15; |
| 修稿时间： | 2002年10月15 |
Studies on regulation of Sini Tang on adrenegic receptors in cardiac function and blood pressure of hemorrhagic shock rats |
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| SHAO Chun-hong,WANG Xiao-liang.Studies on regulation of Sini Tang on adrenegic receptors in cardiac function and blood pressure of hemorrhagic shock rats[J].Chinese Pharmaceutical Journal,2003,38(11):847-850. |
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| Authors: | SHAO Chun-hong WANG Xiao-liang |
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| Institution: | Department of Pharmacology,Insitute of Materia Medica,Chinese Academy of Medical Sciences Peking Union Medical College,Beijing 100050,China |
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| Abstract: | OBJECTIVE To study the protective effect of Sini Tang on cardiac function of hemorrhagic shock rats. METHODS The effect of Sini Tang on hemodynamics of hemorrhagic shock rats and the influence of α and β receptors antagonists were observed. RESULTS Sini Tang improved the LVSP,(dp/dtmax and MAP of hemorrhagic shock rats,and the effects were inhibited by α and β receptors antagonists in different degrees. CONCLUSION Sini Tang can improve the cardiac function and increase the arterial blood pressure of hemorrhagic shock rats.The regulation of α and β receptors may involve in this process. |
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| Keywords: | Sini Tang hemodynamics α receptor antagonist β receptor antagonist |
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