| MMP-1、TIMP-1和U-PA在血管成形术后再狭窄中表达的实验研究 |
| |
| 引用本文： | 张瑞宏,赵进军.MMP-1、TIMP-1和U-PA在血管成形术后再狭窄中表达的实验研究[J].中国急救医学,2002,22(5):257-259. |
| |
| 作者姓名： | 张瑞宏 赵进军 |
| |
| 作者单位： | 1. 哈尔滨铁路中心医院,150001
2. 哈尔滨医科大学第一临床医学院心内科 |
| |
| 基金项目： | 黑龙江省科学技术计划项目(No.G97C18- 2 - 0 6 ) |
| |
| 摘 要： | 目的：本实验以兔髂动脉为模型，探讨基质金属蛋白酶－1（MMP－1），基质金属蛋白酶－1组织抑制剂（TIMP－1）和尿激酶纤溶酶原激活剂（U－PA）在血管成形术后再狭窄中的作用。方法：对48只家兔髂动脉粥样硬化模型血管进行球囊扩张术，分别于术后不同时间行血管造影后处死动物，取扩张血管段用病理方法观察血管形态，用原位杂交法测定MMP－1，TIMP－1和U－PA的mRNA表达，结果：球囊扩张术后各时间点MMP－1和TIMP－1 mRNA始终处于弱表达，没有明显升高；球囊扩张术后1d,U-PA mRNA在内膜和中膜表达增加（＋＋），4d时达高峰（＋＋＋），7d后开始下降并保持弱表达（＋），结论：MMP－1，TIMP－1和U－PA在血管成形术后异常表达，为新生内膜形成的重要原因，可能在成形术后再狭窄中起重要作用。
|
| 关 键 词： | 平滑肌细胞 再狭窄 基质金属蛋白酶－1 基质金属蛋白酶－1组织抑制剂 尿激酶纤溶酶原激活剂 血管成形术 动物实验 |
| 文章编号： | 1002-1949(2002)05-0257-03 |
| 修稿时间： | 2002年2月3日 |
Experimental study for the expression of matrix metalloproteinase-1, tissue inhibitor of matrix metalloproteinase-1 and urokinase of plasminogen activator in restenosis after angioplasty |
| |
| ZHANG Rui-hong ,ZHAO Jin-jun Harbin Railway Central Hospital,Harbin.Experimental study for the expression of matrix metalloproteinase-1, tissue inhibitor of matrix metalloproteinase-1 and urokinase of plasminogen activator in restenosis after angioplasty[J].Chinese Journal of Critical Care Medicine,2002,22(5):257-259. |
| |
| Authors: | ZHANG Rui-hong ZHAO Jin-jun Harbin Railway Central Hospital Harbin |
| |
| Institution: | ZHANG Rui-hong 1,ZHAO Jin-jun 2 1 Harbin Railway Central Hospital,Harbin 150001, 2 Department of Cardiology,the First Affiliated Teaching Hospital,Harbin Medical University,Harbin 150001,China |
| |
| Abstract: | Objective To investigate the function of MMP-1,TIMP-1and U-PA in restenosis after angioplasty. Methods The MMP-1, TIMP-1 and U-PA mRNA were detected by in situ hybridization in the rabbit iliac artery after balloon catheter injury at various time Results The expression of MMP-1,TIMP-1 mRNA keep low levels all the time after angioplasty and increased in atherosclerotic plaques,U-PA mRNA increased at one day,reached maximum on 4 days, decreased at 7 days and remained low levels Conclusion The abnormal expression of MMP-1,TIMP-1 and U-PA may play an important role in migration of vascular smooth muscle cells,formation of neointima and restinosis after angioplasty |
| |
| Keywords: | Smooth muscle cell Restenosis Matrix metalloproteinase-1 Tissue inhibitor of matrix metalloproteinase-1 Urokinase of plasminogen activator |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
