| 复方奥硝唑大黄口腔膜的安全性评价 |
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| 引用本文： | 范春玲,马云秀,邵长江,刘文虎,贺殿. 复方奥硝唑大黄口腔膜的安全性评价[J]. 中国新药杂志, 2010, 0(3) |
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| 作者姓名： | 范春玲 马云秀 邵长江 刘文虎 贺殿 |
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| 作者单位： | 甘肃省肿瘤医院药学部;兰州大学药学院药物化学研究所;兰州市第一人民医院病理科; |
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| 摘 要： | 目的:评价复方奥硝唑大黄口腔膜的安全性。方法:将口腔膜分别贴在健康豚鼠背部和口腔颊侧黏膜上,进行急性皮肤刺激实验和黏膜刺激实验;将药膜浸膏涂抹在牙周膜上,观察对牙周组织的毒性。结果:急性皮肤刺激反应及强度积分值均为0。黏膜刺激实验中未见充血、出血、肿胀、糜烂、溃疡等反应。牙周组织毒性实验中未出现细胞炎症反应。结论:该药膜对皮肤及口腔黏膜无刺激性,对牙周组织无毒性。
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| 关 键 词： | 复方奥硝唑大黄口腔膜 皮肤刺激 黏膜刺激 牙周组织毒性 |
Evaluation of safety of compound ornidazole-rhubarb buccal film |
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| FAN Chun-ling,,MA Yun-xiu,SHAO Chang-jiang,LIU Wen-hu,HE Dian. Evaluation of safety of compound ornidazole-rhubarb buccal film[J]. Chinese Journal of New Drugs, 2010, 0(3) |
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| Authors: | FAN Chun-ling MA Yun-xiu SHAO Chang-jiang LIU Wen-hu HE Dian |
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| Affiliation: | FAN Chun-ling1,2,MA Yun-xiu3,SHAO Chang-jiang3,LIU Wen-hu2,HE Dian2(1 Department of Pharmacy,Gansu Province Tumor Hospital,Lanzhou 730050,China,2 Institute of Medicinal Chemistry,School of Pharmacy,Lanzhou University,Lanzhou 730000,3 Department of Stomatology,First People's Hospital of Lanzhou,China) |
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| Abstract: | Objective:To evaluate the safety of compound ornidazole-rhubarb buccal film.Methods:Acute skin stimulation test and mucous membrane stimulation test were performed on the skin and the oral mucosa of healthy guinea pig.The extract from the buccal film was daubed on the periodontium of Wistar rats to investigate the periodontium toxicity.Results:The response and intensity scores of the acute skin stimulation were both zero.There were no hyperemia,turgidity,debaucjed or ulceration in the oral mucosa.And there ... |
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| Keywords: | compound ornidazole-rhubarb buccal film skin stimulation mucous membrane stimulation periodontium toxicity |
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