| 龙牙楤木总皂苷对大鼠心肌缺血再灌注损伤保护机制的研究 |
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| 引用本文： | 鲁卫星,李明,王婷. 龙牙楤木总皂苷对大鼠心肌缺血再灌注损伤保护机制的研究[J]. 中华中医药杂志, 2011, 0(3): 554-556 |
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| 作者姓名： | 鲁卫星 李明 王婷 |
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| 作者单位： | 北京中医药大学东直门医院;河南中医学院第一附属医院;北京水利医院; |
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| 基金项目： | 国家自然科学基金课题(No.30572461)~~ |
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| 摘 要： | 目的:观察龙牙楤木总皂苷对缺血再灌注损伤心肌炎症因子ICAM-1表达及SOD的影响。方法:可逆性冠脉左前降支结扎缺血45min再灌注6h复制MI/R模型,Wistar雄性大鼠30只,随机分成模型组、龙牙楤木组、波立维组,每组10只。HE染色观察心肌病理学变化,测定心肌SOD活性,ELISA法测定血清sICAM-1的表达。结果:与模型组比较,龙牙楤木总皂苷、波立维均能显著降低缺血再灌注大鼠血清LDH含量,显著升高SOD的活性,缺血45min再灌注6h血清sICAM-1有明显表达,各组之间无统计学差异。结论:龙牙楤木总皂苷对MI/R有保护作用,可能是通过增加SOD的活力,对抗氧自由基对心肌细胞的毒害作用,减轻心肌细胞的损伤而实现的。
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| 关 键 词： | 龙牙楤木总皂苷 心肌缺血再灌注损伤 细胞间黏附分子 超氧化物歧化酶 |
Study of protection mechanism of aralosides on myocardial ischemia/reperfusion injury in rats |
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| LU Wei-xing,LI Ming,WANG Ting. Study of protection mechanism of aralosides on myocardial ischemia/reperfusion injury in rats[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(3): 554-556 |
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| Authors: | LU Wei-xing LI Ming WANG Ting |
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| Affiliation: | LU Wei-xing1,LI Ming2,WANG Ting3(1Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100070,China,2The First Affiliated Hospital of Henan College of TCM,Zhengzhou 450008,3Beijing Shuili Hospital,Beijing 100036,China) |
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| Abstract: | Objective: To investigate the effects of aralosides on expression of inflammatory molecule ICAM-1 and the activity of superoxide dismutase(SOD) in rats after myocardial ischemia/reperfusion(MI/R) injury.Methods: A model of myocardial ischemia 45min followed by 6h reperfusion was made by reversibly ligating coronary left descending artery.30 Wistar rats were divided randomly into 3 groups: ischemia reperfusion group,aralosides group,Plavix group.HE staining was used to observe the pathological changes of myo... |
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| Keywords: | Aralosides Myocardial reperfusion injury Intercellular adhension molecule SOD |
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