| 黄芩苷磷脂复合物制备工艺的研究 |
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| 引用本文： | 许润春,林彦君,吴品江,郑琴,杨明.黄芩苷磷脂复合物制备工艺的研究[J].中华中医药杂志,2011(1):132-134. |
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| 作者姓名： | 许润春 林彦君 吴品江 郑琴 杨明 |
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| 作者单位： | 成都中医药大学;江西中医学院现代中药制剂教育部重点实验室; |
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| 摘 要： | 目的:考察黄芩苷与磷脂形成磷脂复合物的最佳工艺条件。方法:以黄芩苷与磷脂的结合百分率为评价指标,采用单因素考察和正交设计试验进行系统的研究,考察了反应溶剂类型、药物与磷脂投料比例、药物浓度、反应时间、反应温度等因素对磷脂复合物形成的影响。结果:确定了黄芩苷磷脂复合物的最佳制备条件,即在55℃下以四氢呋喃为反应溶剂,黄芩苷与大豆磷脂最佳比例为1:2,反应系统中黄芩苷浓度为2.5mg/mL,反应时间为1h。结论:黄芩苷磷脂复合物的形成受溶剂类型、反应物浓度和反应温度的影响较大;文章所确定的工艺稳定可行。
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| 关 键 词： | 黄芩苷 磷脂复合物 制备工艺 |
Research on preparation of baicalin-phospholipid complex |
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| XU Run-chun,LIN Yan-jun,WU Pin-jiang,ZHENG Qin,YANG Ming.Research on preparation of baicalin-phospholipid complex[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(1):132-134. |
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| Authors: | XU Run-chun LIN Yan-jun WU Pin-jiang ZHENG Qin YANG Ming |
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| Institution: | XU Run-chun1,LIN Yan-jun1,WU Pin-jiang1,ZHENG Qin2,YANG Ming1,2(1Chengdu University of TCM,Chengdu 611137,China,2Key Laboratory of TCM Preparation,Jiangxi University of TCM,Ministry of Education,Nanchang 330004,China) |
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| Abstract: | Objective: To study the optimum conditions for the formation of baicalin complex with phospholipids.Methods: A reasonable criterion of accurate evaluation was established by testing the reaction solvent type,temperature,time,the ratio of baicalin to phospholipid and the concentration of reactants were examined and the orthographic design was used and the best preparation technology was determined.Results: The optimized preparation conditions for baicalin phytosomes were obtained as follows: Solvent was tetr... |
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| Keywords: | Baicalin Phospholipid complex Preparation |
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