| 氢化可的松诱导大鼠类阳虚状态的动态观察 |
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| 引用本文： | 刘欣,张冰,刘小青,崔一然. 氢化可的松诱导大鼠类阳虚状态的动态观察[J]. 中华中医药杂志, 2011, 0(1): 126-128 |
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| 作者姓名： | 刘欣 张冰 刘小青 崔一然 |
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| 作者单位： | 北京中医药大学中药学院; |
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| 基金项目： | 国家重点基础研究发展计划(973计划)(No.2007CB512605); 北京中医药大学自主选题项目(No.JYBZZ-XS031)~~ |
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| 摘 要： | 目的:通过对肾上腺皮质功能、物质能量代谢等相关指标的检测,动态观察氢化可的松诱导大鼠类阳虚表现,以确定其类阳虚状态持续时间,为临床药物干预提供参考。方法:将SD雄性大鼠随机分为正常组、模型组,模型组肌注氢化可的松20mg/kg,正常组注射等量的生理盐水,于注射第8、15、22d时动态眼眶取血,第29d时腹腔静脉取血,分别对血中的17-羟皮质类固醇(17-OHCS)、甘油三酯(TG)、总胆固醇(TC)、乳酸脱氢酶(LDH)、促甲状腺激素(TSH)、三碘甲腺原氨酸(T3),甲状腺素4(T4)指标进行检测。结果:与正常组比,模型组在第8d时,T3、LDH升高;第15、22d时,17-OHCS、TC、LDH、TSH、T3指标均降低,而TG升高;第29d除17-OHCS、TC降低外,其他未见显著差异。结论:初步确定氢化可的松诱导大鼠类阳虚状态持续时间,为注射第15-22d。
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| 关 键 词： | 氢化可的松 类阳虚 持续时间 |
Dynamic experimental study on rat's analogue yang deficiency syndrome induced by hydrocortisone |
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| LIU Xin,ZHANG Bing,LIU Xiao-qing,CUI Yi-ran. Dynamic experimental study on rat's analogue yang deficiency syndrome induced by hydrocortisone[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(1): 126-128 |
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| Authors: | LIU Xin ZHANG Bing LIU Xiao-qing CUI Yi-ran |
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| Affiliation: | LIU Xin,ZHANG Bing,LIU Xiao-qing,CUI Yi-ran(Chinese Pharmacy Department of Beijing University of Chinese Medicine,Beijing 100102,China) |
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| Abstract: | Objective: To study the stability time and provide reference for clinical intervention of the rat's analogue yang deficiency syndrome induced by hydrocortisone,according to detect the related index of adrenal cortex function,and material energy metabolism and so on.Methods: SD male rats were randomly divided into normal and model group;Normal group was injected Sodium Chloride and model group was injected hydrocortisone.The index in blood of 17-OHCS,TG,TC,LDH,TSH,T3,T4 were detected on 8th,15th,22th from ey... |
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| Keywords: | Hydrocortisone Analogue yang deficiency Stability time |
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