隔物灸治疗寒湿凝滞型原发性痛经的疗效及其对经血和血清PGF2α含量的影响

目的:探讨隔物灸治疗寒湿凝滞型原发性痛经的作用机制。方法:以隔物灸治疗寒湿凝滞型原发性痛经患者105例,并设中药月月舒作对照(104例)。治疗3个疗程后,观察临床疗效,同时在治疗前后对两组各10例进行经血前列腺素F2α(PGF2α)含量测定和两组各40例进行经期血清PGF2α含量检测。结果:治疗组疗效明显优于对照组(P<0.05)。治疗后两组患者经血PGF2α水平较治疗前均有不同程度降低,但治疗组优于对照组(P<0.05);两组患者治疗前血清PGF2α水平均较正常组明显升高,治疗后两组均有不同程度降低,但治疗组优于对照组(P<0.05)。结论:隔物灸对寒湿凝滞型原发性痛经患者有明显治疗作用,其作用机制之一可能是通过调节PGF2α水平而发挥止痛效应。

Effect of ginger-partitioned moxibustion and infulence on menstrual and serum PGF2α contents in patients with primary dysmenorrhea

Objective: To expolore the mechanism of ginger-partitioned moxibustion in the treatment of cold-damp stagnation type Primary Dysmenorrhea(PD) patients.Methods: A total of 209 PD patients were randomized into moxibustion group(n=105) who were treated with ginger-partitioned moxibustion,and control group(n=104) who were asked to take Yueyueshu Granules.Before and after 3 courses’ treatments,Menstrual ProstaglandinF2α(PGF2α) and Serum PGF2α Contents in patients partly and normal women experiencing menstrual period were determined.Results: After the treatment,the therapeutic effect of moxibustion group was significantly better than that of control group(P<0.05).After the treatment,self-comparison of both moxibusion and control groups showed that menstrual and serum PGF2α decreased significantly,and the therapeutic effect of moxibusion goup was markedly superior than that of contorl group in lowing menstrual and serum PGF2α(P<0.05).Conclusion: Ginger-partitioned moxibusion is effective in relieving PD patients’ abdominal pain,which may be closely associated with its actions in PGF2α contents.