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Combination Inhalers Containing Inhaled Corticosteroids and Long-Acting β2-Agonists: Improved Clinical Efficacy and Dosing Options in Patients with Asthma
Authors:Jaro Ankerst
Affiliation: a Department of Medicine, University Hospital Lund, Lund, Sweden
Abstract:Combination therapy with inhaled corticosteroids (ICS) and long-acting β2-agonists (LABA) is a recognized treatment for adults with moderate to severe asthma. The introduction of inhalers containing both an ICS and a LABA simplifies treatment and improves asthma control. This review discusses clinical evidence that budesonide/formoterol and salmeterol/fluticasone are effective and well tolerated in asthma treatment. Moreover, the rapid onset of effect and long duration of action of budesonide and formoterol make once-daily dosing, adjustable maintenance dosing, and the novel treatment strategy of using budesonide/formoterol for maintenance and as needed for symptom relief, valuable treatment options for patients with asthma.
Keywords:Symbicort®  budesonide/formoterol  Seretide®/Advair®  salmeterol/fluticasone  long-acting β2-agonist  inhaled corticosteroid
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