| 2''''-乙酰基-3-酮基-10,11-脱水-6-O-甲氧基红霉素的合成 |
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| 引用本文： | 易红,许先栋. 2''''-乙酰基-3-酮基-10,11-脱水-6-O-甲氧基红霉素的合成[J]. 中国新药杂志, 2005, 14(5): 581-582 |
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| 作者姓名： | 易红 许先栋 |
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| 作者单位： | 中国医学科学院,中国协和医科大学医药生物技术研究所,北京,100050 |
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| 摘 要： | 目的:合成泰利霉素中间体2'-乙酰基-3-酮基-10,11-脱水-6-O-甲氧基红霉素.方法:以6-O-甲氧基红霉素为起始原料,经脱水、酸水解、乙酰化和氧化得到目标产物.结果:以6-O-甲氧基红霉素计,总收率79.9%.目标产物的光谱数据与文献报道一致.结论:该方法合成操作简单,反应条件温和.
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| 关 键 词： | 2'-乙酰基-3-酮基-11,12-脱水-6-O-甲氧基红霉素 泰利霉素 合成 |
| 文章编号： | 1003-3734(2005)05-0581-02 |
Synthesis of 2'''' -acetyl-3-oxo- 10,11-dehydro -6- O-methoxyerythromycin |
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| YI Hong,XU Xian-dong. Synthesis of 2'''' -acetyl-3-oxo- 10,11-dehydro -6- O-methoxyerythromycin[J]. Chinese Journal of New Drugs, 2005, 14(5): 581-582 |
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| Authors: | YI Hong XU Xian-dong |
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| Abstract: | Objective: To synthesize 2'-acetyl-3-oxo-10, 11-dehydro-6-O-methoxyerythromycin, an intermediate of telithromycin. Methods: Starting from 6-O-methoxyerythromycin, 2'-acetyl-3-oxo-10, 11-dehydro-6-O-methoxyerythromycin was synthesized via dehydration,acidic hydrolysis, acetylation and oxidation. Results: A total yield of the target product was 79.9%. The structure of the target product was confirmed by the spectral analyses. Conclusion: A simple and easily manipulated way to synthesize the intermediate was attainable. |
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| Keywords: | 2'-acetyl-3-oxo-10 11-dehydro-6-O-methoxyerythromycin telithromycin synthesis |
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