兔脑局部冷冻对血液流变性的影响

目的 :探讨脑局部冷冻兔血液流变学变化及蝮蛇抗栓酶对其的保护作用。方法 :日本白色兔 2 4只 ,分为三组 :单纯冷冻组 (Ⅰ组 )、生理盐水对照组 (Ⅱ组 )、药物治疗组 (Ⅲ组 ) ,分别检测脑局部冷冻前后不同时相血液流变学指标的变化。结果 :Ⅰ组、Ⅱ组脑局部冷冻后血液流变学指标明显改变 ,与冷冻前比较 :ηb、ηp、ESR、K值、EAI明显升高 (P <0 .0 5或 0 .0 1)。Ⅲ组脑局部冷冻前后比较 ,差别无显著性意义 (P >0 .0 5 )。Ⅲ组冷冻后不同时相血液流变学指标明显低于Ⅰ组和Ⅱ组 (P <0 .0 5 )。结论 :兔脑局部冷冻能引起血液流变性改变 ,蝮蛇抗栓酶对兔脑局部冷冻造成的血液流变性损害有保护作用。目的 :探讨脑局部冷冻兔血液流变学变化及蝮蛇抗栓酶对其的保护作用。方法 :日本白色兔 2 4只 ,分为三组 :单纯冷冻组 (Ⅰ组 )、生理盐水对照组 (Ⅱ组 )、药物治疗组 (Ⅲ组 ) ,分别检测脑局部冷冻前后不同时相血液流变学指标的变化。结果 :Ⅰ组、Ⅱ组脑局部冷冻后血液流变学指标明显改变 ,与冷冻前比较 :ηb、ηp、ESR、K值、EAI明显升高 (P <0 .0 5或 0 .0 1)。Ⅲ组脑局部冷冻前后比较 ,差别无显著性意义 (P >0 .0 5 )。Ⅲ组冷冻后不同时相血液流变学指标明显低于Ⅰ组和Ⅱ组 (P <0 .0 5 )。结论 :兔脑局部冷冻?

Influences of Local Brain Freezing on Hemorheological Property in Rabbits

Objective: An experiment on rabbits was conducted to explore the influences of local brain freezing treatment on hemorheology as well as the intervention by Ahalysantinfarctasum(AF).Method: 24 Japanese Albino rabbits were randomly divided into 3 groups of 8 each,i.e.,simple brain freezing(BF),freezing plus normal saline(BF+SL) and freezing plus Ahalysantinfarctasum(BF+AF).The details of hemorheologyical indexes were measured separately in different phases before and after the treatment.Results: There were remarkable changes in the BF and BF+SL after freezing.The hemorheological indexes such as ηb,ηp,ESR,K value and EAI exhibited remarkable changes compared with those before freezing( P<0.05 ).On the contrary,in the BF+AF,comparisons between before and after the treatment revealed no significant differences( P>0.05 ) in hemorheological indexes.Furthermore,the hemorheological indexes in different phases after the treatment in the BF+AF were obviously better than in the BF and in the BF+SL( P<0.05 ).Conclusion: The results showed that local brain freezing can induce hemorheological abnormalities.Whereas AF prevents hemorheology from the dysfunction and abnormalities caused by BF.