| 醛固酮合成酶基因-344T/C多态性与高血压病相关性研究 |
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| 引用本文： | 侯晓菲,孙晓健,刘少荣,刘文波,张传焕.醛固酮合成酶基因-344T/C多态性与高血压病相关性研究[J].中国优生与遗传杂志,2005,13(8):24-25. |
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| 作者姓名： | 侯晓菲 孙晓健 刘少荣 刘文波 张传焕 |
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| 作者单位： | 1. 青岛大学医学院附属烟台毓璜顶医院肾内科,山东,烟台,264000
2. 青岛大学医学院附属烟台毓璜顶医院心内科,山东,烟台,264000 |
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| 摘 要： | 目的研究醛固酮合成酶基因-344T/C多态性是否与原发性高血压相关.方法多聚酶链反应-限制性片段长度多态性技术检测原发性高血压和对照组醛固酮合成酶基因-344T/C多态性,χ2检验比较各组基因型和等位基因频率.结果对照组TT、TC和CC基因型频率分别为48%、43%和9%,高血压病组TT、TC和CC基因型频率分别为43%、47%和10%;对照组T、C等位基因频率分别为69%和31%,高血压病组T、C等位基因频率分别为66%和34%.经χ2检验两组之间基因型和等位基因频率差异均无显著性(P＞0.05).结论本研究尚不支持醛固酮合成酶基因-344T/C多态性与原发性高血压存在相关性.
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| 关 键 词： | 醛固酮合成酶 基因多态性 原发性高血压 |
| 文章编号： | 1006-9534（2005）08-0024-02 |
| 收稿时间： | 2004-11-15 |
| 修稿时间： | 2004年11月15 |
Association between CYP1 1B2 gene - 344T/C polymorphism and essential hypertension |
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| HOU Xiao-fei,SUN Xiao-jian,LIU Shao-rong,LIU Wen-bo,ZHANG Chuan-huan.Association between CYP1 1B2 gene - 344T/C polymorphism and essential hypertension[J].Chinese Journal of Birth Health & Heredity,2005,13(8):24-25. |
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| Authors: | HOU Xiao-fei SUN Xiao-jian LIU Shao-rong LIU Wen-bo ZHANG Chuan-huan |
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| Abstract: | Objective:To investigate whether the -344T/C polymorphism of CYP11B2 gene is associated with essential hypertension in Han nationalities.Methods:-344T/C polymorphism was determined by polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP) in controls and hypertensives.Results :No significant differences were found in genotype distribution or allele frequency between groups of control and primary hypertension(P>0.05).Conclusion:No relationship was found between the -344T/C polymorphism of CYP11B2 gene and essential hypertension in Han nationalities. |
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| Keywords: | Aldosterone synthase Gene polymorphism Essential hypertension |
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