Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction |
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| Authors: | Bae Eun-Ah Park Eun-Kyung Yang Hye-Joung Baek Nam-In Kim Dong-Hyun |
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| Affiliation: | College of Pharmacy, Kyung Hee University, Seoul, Korea. |
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| Abstract: | The antiallergic effect of hinokiresinol isolated from the whole plant of TRAPA Pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited beta-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC50 value of 98 microM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-alpha in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE. |
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