| 西咪替丁对过敏性紫癜患者T细胞亚群及白细胞介素活性的影响 |
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| 引用本文： | 赵刚,符仁义,杨崇礼,罗春华,李丰益. 西咪替丁对过敏性紫癜患者T细胞亚群及白细胞介素活性的影响[J]. 四川大学学报(医学版), 2000, 0(1) |
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| 作者姓名： | 赵刚 符仁义 杨崇礼 罗春华 李丰益 |
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| 作者单位： | 华西医科大学附属第二医院儿科!成都610041广州武警部队总医院(赵刚)，华西医科大学附属第二医院儿科!成都610041(符仁义，杨崇礼，罗春华，李丰益) |
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| 摘 要： | 为探讨西咪替丁对过敏性紫癜患者细胞免疫功能的影响 ,用双标记流式细胞技术测 T细胞亚群 ,MTT比色法测外周血 IL - 2水平 ,评价治疗前后的变化。结果显示 :治疗后 CD3 、CD4 T细胞的百分比、CD4 /CD8 的比值及 IL- 2水平较治疗前升高 (P<0 .0 5 ) ,CD8 T细胞治疗前后无变化。结论 :西咪替丁能促进 T细胞增殖分化 ,增强 TH1 细胞功能
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| 关 键 词： | 西咪替丁 过敏性紫癜 细胞免疫 |
The Lymphocyte Subset and Blood Interleukin 2 Level in Children with Henoch Schnlein Purpura before and after Cimetidine Treatment |
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| Zhao Gang,Fu Renyi,Yang Chongli,Luo Chunhua,Li Fengyi. The Lymphocyte Subset and Blood Interleukin 2 Level in Children with Henoch Schnlein Purpura before and after Cimetidine Treatment[J]. Journal of Sichuan University. Medical science edition, 2000, 0(1) |
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| Authors: | Zhao Gang Fu Renyi Yang Chongli Luo Chunhua Li Fengyi |
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| Affiliation: | Zhao Gang,Fu Renyi,Yang Chongli,Luo Chunhua,Li Fengyi. Department of Pediatrics,The Second Affiliated Hospital,WCUMS,Chengdu 610041 |
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| Abstract: | The objective of this study was to evaluate the effect of cimetidine treatment on cellular immunity in children with Henoch Schnlein purpura. T cell subset was detected by double marker flow cytometry and the level of IL 2 in peripheral blood was measured by MTT method, before and after cimetidine treatment.The results showed that CD 3, CD 4 T cell subset, CD 4 / CD 8 ratio, and blood IL 2 level increased after the treatment ( P < 0 05). There was no significant change in CD 8 T subset after the treatment. These findings indicate that cimetidine can promote T lymphocyte proliferation and differentiation, especially T H1 lymphocyte activity. |
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| Keywords: | Cimetidine Henoch Schnlein purpura Cellular immunity |
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