大肠癌组织胃泌素与c—myc,c—fos表达的关系

目的 研究大肠癌组织中胃泌素与癌基因ｃ－ｍｙｃ、ｃ－ｆｏｓ表达的关系，以探讨胃泌素对大肠癌的促增殖作用机理。方法 采用免疫组化ＳＰ法检测４８例大肠癌患者癌组织及癌旁粘膜胃泌素和癌基因ｃ－ｍｙｃ、ｃ－ｆｏｓ的表达。结果 大肠癌组织胃泌素阳性率为３９．５８％，高分化腺癌明显高于低分化和粘液腺癌（Ｐ〈０．０５）。癌组织的ｃ－ｍｙｃ和ｃ－ｆｏｓ表达阳性率显著高于癌旁粘膜和正常粘膜。胃泌素阳性组癌组织ｃ－ｍｙｃ和ｃ－ｆｏｓ表达阳性率分别为７８．９４％和７３．６８％，胃泌素阴性组分别为３７．９３％和３１．０４％，差异均有显著性意义（Ｐ〈０．０５，Ｐ〈０．０１）。结论 部分大肠癌细胞通过自分泌方式产生胃泌素，可能通过增加ｃ－ｍｙｃ、ｃ－ｆｏｓ等癌基因的表达，从而刺激癌细胞的价值。

THE RELATIONSHIP BETWEENGASTRIN AND c-myc

Objective To study the relationship between gastrin and c myc, c fos expression in colorectal cancerous tissue and the mechanism of gastrin effect on colorectal cancer.Methods The gastrin and c myc, c fos expression in 48 cases of colorectal cancerous tissue and cancer adjacent mucosa were detected with immunohistochemistry techniques. Results The positive rate of gastrin in colorectal cancerous tissue was 39.58%. The rate of the well differentiated adenocarcinoma was higher than that of the poorly differentiated and mucinous adenocarcinoma( P<0.05) . The positive rates of c myc and c fos in colorectal cancerous tissue were higher than those in cancer adjacent and normal mucosa. The positive rate of c myc and c fos in the group with gastrin positive expression were 78.94% and 73.68%, higher than those in the group with negative gastrin expression(37.93% and 31.04%). Conclusion Some of colorectal cancer cells formed and secreted gastrin through autocrine. The increase of c myc, c fos etc oncogene expression probably stimulate the cancer cells proliferation.