PET-CT与钼靶X线、B超定性诊断乳腺癌的临床对比研究

目的 探讨18F-氟代脱氧葡萄糖(18F-FDG)PET-CT诊断乳腺癌的临床应用价值。方法 60例临床怀疑乳腺癌的患者分别行B超、钼靶X线乳腺摄影和PET-CT检查。结合术后病理,比较PET-CT、B超、钼靶X线乳腺摄影诊断乳腺癌的结果。结果 手术病理证实乳腺癌48例,良性病变12例。PET-CT目测法诊断乳腺癌的灵敏度、特异度、准确率及阳性预测值分别为93.8%、83.3%、91.7%及95.7%,钼靶X线法分别为81.3%、83.3%、81.7%及95.1%,B超法分别为85.4%、83.3%、85.0%及95.3%。三种方法对乳腺癌的诊断效能无显著差异性(χ2=3.40,P>0.5)。结论 18F-FDGPET-CT诊断乳腺癌具有很好的临床应用价值,并能对乳腺癌的分期提供更多的信息。

Evaluation of PET-CT versus mammography and ultrasonography in detecting breast neoplasms

Objective To evaluate the clinical value of 18F-fluorodeoxyglucose(18F-FDG) PET-CT imaging in detecting breast cancer.Methods 60 patients with suspicious masses underwent 18F-FDG PET-CT imaging, mammography and ultrasonography respectively. The results of the histopathology after surgery were used as diagnostic golden standard. The uptaking of 18F-FDG in the breast masses was analyzed using semiquantitative and qualitative methods. The findings of PET-CT,mammography and ultrasonography in detecting breast cancer were compared.Results 48 malignant and 12 benign breast lesions of the 60 patients were proven histologically after surgery. The sensitivity, specificity, accuracy and positive predictive value obtained by PET-CT were 93.8%,83.3%,91.7% and 95.7%, respectively, and which were 81.3%,83.3%,81.7%,95.1% and 85.4%,83.3%,85.0%,95.3% with mammography and ultrasonographic. In the diagnostic ability among the three methods there was no significant difference showed(χ2=3.40,P>0.5).Conclusions PET-CT has higher degree of sensitivity, specificily and higher positive predictive value in breast cancer diagnosis and staging comparing to the mammography and ultrasonographic.